Journal Browser

Go Edit a Special Issue


Special Issue Title:

Opioid Free Analgesia: Postoperative analgesia

Deadline for manuscript submissions: 01 February 2022

Print Special Issue Flyer (12)

Special Issue Editor

  • Guest Editor

    Dr. Dimosthenis PetsasE-MailWebsite

    MD Pg.Dip; Consultant anesthetist at General Hospital of Serres in northern Greece; An associate member of the Royal College of Anaesthetists, UK; Possess a Postgraduate Diploma in regional anesthesia by Montpellier University, France

    Interests: US-guided regional anesthesia and analgesia, Postoperative pain, Trauma anesthesia

Special Issue Information

Postoperative pain remains a big problem complicating patients’ perioperative course. It is a multifactorial problem influenced by gender, age, personal beliefs, preoperative anxiety, surgical diagnosis and intraoperative factors. Postoperative analgesia may be influenced by interventions done pre-, intra- and postoperatively. Inadequate postoperative analgesia might have short term complications (inadequate breathing, mobilization delays, anxiety as well as patient and family stress) and long term complications as chronic postsurgical pain, depression and disabilities.

For many years the mainstay in postoperative analgesia has been the use of the WHO ladder. The WHO ladder includes paracetamol, NSAIDs and opioids. Many physicians consider opioids the main medication in treating postoperative pain. Opioids have some well documented side effects (respiratory depression, constipation, tolerance, addiction and hyperalgesia). Exogenous opioids have been implicated in affecting the immune system (immune system depression).The latter has been shown inconsistently in publications. The global problem of the opioid epidemic stresses the importance of reducing opioids usage.

The use of regional techniques is the main method facilitating reduction and abandonment of opioids. For many years the gold standard regional technique has been the epidural analgesia. Unfortunately epidurals have some potential serious side effects (hemodynamic instability, nausea, and vomiting and muscle weakness). It is no longer considered the gold standard of postoperative analgesia.

The global trend is towards abandoning opioid use. Peripheral nerve blocks (mainly catheter techniques) have led to a pain free postoperative period. Progress looks promising. Development of nerve blocks, compartment blocks (like Fascia Iliaca Block), plane blocks (like TAP block, Rectus Sheath and Erector Spinae Plane Block) as well as all paravertebral blocks has provided the ability to cover all anatomical areas with little (or none) side effect. The trend in regional anesthesia is moving from aiming specific nerves towards injecting in planes and compartments, increasing techniques’ safety and simplicity.

From paravertebral techniques we witnessed the development of ESP block which is a much easier and safer technique.

The challenge is using these modern techniques to have a perfectly pain free and comfortable patient in the postoperative period. There are still hospitals in many countries that do not have the ability of performing US guided PNB due to lack of training or equipment. The training of perioperative physicians in these techniques is essential and the long term profit from equipment supply will surely be a cost effective investment.

We welcome articles, reviews and commentaries focused on postoperative analgesia. Your experience especially involving modern techniques will surely improve our practice and spread the new trends in this field. Of huge importance is your experience with PNB minimizing opioid usage. 


Postoperative pain, Analgesia, Opioid free, Peripheral nerve blocks

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Signa Viate is an international peer-reviewed open access journal published by MRE Press. As of January 2021, Signa Vitae will change to a bimonthly journal. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

Share This Special Issue

Plan Papers (0 papers)

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

IndexCopernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time