Aims and scope

The aim of Signa Vitae (SV) is to be an unbiased and permanent forum for clinical anesthesia, intensive care, emergency and pain medicine. It serves professionals dedicated to all these relevant fields, as a tool for easier and more effective experiences and science sharing, with the ultimate goal to improve patients’ outcome. The scope of Signa Vitae is broad. It encompasses all aspects of clinical practice and fundamental research at the basis of anesthesia, intensive care, emergency and pain medicine, both in children and adults. It will better inform and educate the global scientific and medical community on the advancements in the fields at the basis of survival and a better quality of life, as stated in the appealing Latin version of its name: "Signs of life". 


Open Access

21st Panhellenic Congress on Regional Anaesthesia, Pain Management and Palliative Care

Athina Vadalouka,Ioanna Siafaka,Maria Kokolaki

DOI: 10.22514/sv.2021.152

Abstract ( 642 ) PDF (2.18 MB) ( 184 )

Open Access

Palliative care: Words or touch in the pre- intubation phase of critically ill Covid 19 patients

Vasileios Flampouraris,Sotirios Kalinoglou,Stella Kandreviotou,Anastasia Niaka,Georgios Dimitriou,Maria Kokolaki

DOI: 10.22514/sv.2021.154

Abstract ( 495 ) PDF (495.71 kB) ( 155 )

Open Access

Ethical dilemmas in managing severe burns:Is there a place for palliative care?

Eleni Diamantaki,Vasileia Nyktari,George Papastratigakis,Georgios Stefanakis,Periklis Vasilos,Dimitrios Kouvidakis,Alexandra Papaioannou

DOI: 10.22514/sv.2021.155

Abstract ( 490 ) PDF (174.69 KB) ( 125 )

Open Access

Relationship between depression, anxiety, and pain perception in diabetic neuropathy

Maria Nianiarou,Zoi Gambopoulou,Dimitra Solomou,Marianna Karathanou,Dimitra Papadopoulou,Evmorfia Stavropoulou

DOI: 10.22514/sv.2021.156

Abstract ( 463 ) PDF (161.5 kB) ( 153 )

Open Access

Audit of patients of the pain clinic of the University Hospital of Heraklion with neuropathic pain during the period 2019–2020

Emmanouela Koutoulaki,Amalia Mathioudaki,Vasileia Nyktari,Georgios Stefanakis,Periklis Vasilos,Stavroula Ilia,Georgios Frantzeskos,Alexandra Papaioannou

DOI: 10.22514/sv.2021.158

Abstract ( 434 ) PDF (237.67 KB) ( 139 )

Open Access

Shpenopalatine ganglion block using the Tx360 nasal applicator for the treatment of trigeminal neuralgia: A pilot study

Athanasia Tsaroucha,Christina Orfanou,Aikaterini Melemeni,Nikolaos Fyrfiris,Kassiani Theodoraki

DOI: 10.22514/sv.2021.160

Abstract ( 450 ) PDF (193.49 kB) ( 152 )

Open Access

Double and single edge sign hydrodissection: An experimental study

Alexis Triantopoulos,Paraskevi Dedopoulou,Aggeliki Athanasopoulou,Christiana Gkeka,Theodora Mpouzi,Christina Arachoviti

DOI: 10.22514/sv.2021.161

Abstract ( 379 ) PDF (755.62 kB) ( 159 )

Open Access

Ropivacaine toxicity after surgical wound local infiltration in a patient with renal failure

Chara Savva,Efthimia Kalliontzi,Eleni Papaioannou,Dimitrios Karousos,Aikaterini Liosi,Despoina Danassi,Aikaterini Lampadariou

DOI: 10.22514/sv.2021.162

Abstract ( 308 ) PDF (197.1 kB) ( 145 )

Open Access

Peripheral nerve block for leg amputation in a high risk patientꓽ Case report

Sofia Papantonaki,Aikaterini Lappa,Maria Dermitzaki,Athanasia Dragatsiki,Stavros.Chochlidakis

DOI: 10.22514/sv.2021.163

Abstract ( 385 ) PDF (179.61 kB) ( 135 )

Open Access

The effectiveness of Bilateral Erector Spinae Plane Block in reducing perioperative opioid administration in patients undergoing Laparoscopic Cholecystectomy

Freideriki Sifaki,Ioannis Mantzoros,Eleni Koraki,Stella Bagntasarian,Panagiotis Christidis,Vaia Tsapara,Kassiani Theodoraki

DOI: 10.22514/sv.2021.164

Abstract ( 397 ) PDF (206.37 kB) ( 156 )

Open Access

Epidural blood patch in the management of the syndrome of spontaneous intracranial hypotension: An effective therapeutic approach

Ζoi Masourou,Nikolaos Papagiannakis,Dimos-Dimitrios Mitsikostas,Kassiani Theodoraki

DOI: 10.22514/sv.2021.165

Abstract ( 382 ) PDF (269.15 kB) ( 125 )

Open Access

Comparison of two different local anesthetic infusion methods (with or without opioids) for epidural analgesia after cesarean section delivery

Spanopoulos Konstantinos,Papagiannopoulou Ofilia,Kousidis Ioiannis P,Anagnostou Georgios,Zografidou Polixeni,Tsiotsiou Maria,Gogali Despoina,Pinas Dimitrios,Grenda Georgia,Grigoriou Ioulia,Goutziomitrou Evangelia

DOI: 10.22514/sv.2021.166

Abstract ( 376 ) PDF (208.92 KB) ( 139 )

Open Access

Comparison of two different methods for labor analgesia depending on the mode of epidural infusion administration (continuous or intermittent)

Spanopoulos Konstantinos,Anagnostou Georgios,Kousidis Ioiannis P.,Papagiannopoulou Ofilia,Zografidou Polixeni,Tsiotsiou Maria,Gogali Despoina,Pinas Dimitrios,Grenda Georgia,Grigoriou Ioulia,Goutziomitrou Evangelia

DOI: 10.22514/sv.2021.167

Abstract ( 342 ) PDF (224.53 KB) ( 122 )

Open Access

Sphenopalatine Ganglion Block (SPG) for the treatment of migraine

Sofia Papantonaki,Aikaterini Lappa,Athanasia Dragatsiki,Evaggelia Gavrilaki

DOI: 10.22514/sv.2021.170

Abstract ( 353 ) PDF (194.23 kB) ( 157 )

Open Access

Chronic pain in patients with coeliac disease: Cross sectional study

Christianna Ioannou,Andreas Liampas,Artemios Artemiadis,Stefania Kalampokini,Panagiotis Bargiotas,Georgios Hadjigeorgiou,Panagiotis Zis

DOI: 10.22514/sv.2021.171

Abstract ( 322 ) PDF (223.05 kB) ( 126 )

Open Access

Chronic pain in patients with COVID-19: Cross sectional study

Andreas Liampas,Christianna Ioannou,Artemios Artemiadis,Georgios Hadjigeorgiou,Panagiotis Zis

DOI: 10.22514/sv.2021.172

Abstract ( 338 ) PDF (224.09 kB) ( 143 )

Open Access

COVID 19 pandemic influence on Pain Clinic patients of “Laikon” General Hospital of Athens

Aikaterini Liossi,Eleni Papaioannou,Efthimia Kalliontzi,Efthimios Mavrommatis,Christina Koufopoulou,Aggeliki Maniati,Chara Paloumbi,Elli Papadopoulou,Aikaterini Lambadariou

DOI: 10.22514/sv.2021.173

Abstract ( 357 ) PDF (239.73 kB) ( 132 )

Open Access

The effect of Reflexology in patients with Fibromyalgia

Sofia Raptopoulou,Maria Kouri,Athina Vadalouka,Athanasia Tsaroucha

DOI: 10.22514/sv.2021.175

Abstract ( 361 ) PDF (223 kB) ( 164 )

Open Access

Perioperative Analgesia in Major Oncology operations for the prolepsis of persistence of Chronic Neuropathic Pain

Dionysia Boura,Eirini Anastassopoulou,Paraskevi Koufopoulou,Koutouzis Stavros,Katsipoulakis Antonios,Papadopoulos George,Vaivai Anastasia,Tsolou Archontia

DOI: 10.22514/sv.2021.176

Abstract ( 413 ) PDF (281.19 kB) ( 145 )

Open Access

Perioperative analgesia for the prolepsis of persistence of post-thoracotomy chronic neuropathic pain

Dionysia Boura,Eirini Anastassopoulou,Paraskevi Koufopoulou,Nikolaos Anastasiou,Katsipoulakis Antonios,Lambropoulou Konstantina

DOI: 10.22514/sv.2021.177

Abstract ( 395 ) PDF (171.15 KB) ( 164 )

Open Access

Anesthetic management of a patient with Takotsubo syndrome undergoing hip fracture repair

Maria Diakomi,Alexandros Makris,Maria Tileli,Stella Potamianou,Konstantinos Konstantopoulos

DOI: 10.22514/sv.2021.179

Abstract ( 391 ) PDF (322.88 kB) ( 130 )

Open Access

Post-surgical analgesia management with transdermal buprenorphine patch on a patient with compartment syndrome after tibia plateau fracture with multiple operations before the end of his rehabilitation

Ioannis Chronakis,Ioannis Ktistakis,Konstantinos Mastrantonakis,Evaggelia Vrontaki,Emmanouil Daskalogiannakis,Vassiliki Zotou,Anastasia Garmpi,Charalambos Christogiannis,Georgios Velivasakis

DOI: 10.22514/sv.2021.180

Abstract ( 415 ) PDF (244.65 kB) ( 167 )

Open Access

Assessment of dyspnoea in Covid 19 patients using modified Borg scale

Vasileios Flampouraris,Sotirios Kalinoglou,Stella Kandreviotou,Bogdan Raitsiou,Maria Kokolaki,Xanthi Tsiafaki

DOI: 10.22514/sv.2021.182

Abstract ( 352 ) PDF (196.61 kB) ( 131 )

Open Access

Posttraumatic stress in Covid 19 patients after extubation in an intensive care unit (ICU)

Vasileios Flampouraris,Maria Kokolaki,Stella Kandreviotou,Anastasia Niaka,Andromachi Papadopoulou

DOI: 10.22514/sv.2021.183

Abstract ( 297 ) PDF (212.36 kB) ( 144 )

Published Ahead of Print

Open Access Special Issue

Gout flare in the critical care setting: diagnostic challenges and treatment options

Panchalee Satpanich,Kanon Jatuworapruk

Online publish date: 20 October 2021

DOI: 10.22514/sv.2021.217

Abstract ( 241 ) PDF (846.47 KB) ( 145 )

Open Access Special Issue

The impact of Coronavirus disease 19 on emergency volume in Northern Taiwan

Chien Wei Cheng

Online publish date: 11 October 2021

DOI: 10.22514/sv.2021.215

Abstract ( 340 ) PDF (972 KB) ( 133 )

Open Access

Icariside II regulates TLR4/NF-κB signaling pathway to improve septic lung injury

Yan Li,Baishun Lin

Online publish date: 11 October 2021

DOI: 10.22514/sv.2021.216

Abstract ( 244 ) PDF (1.16 MB) ( 113 )

Open Access

Use of convalescent plasma in the treatment of critically ill COVID-19 patients: a study protocol

Amar Ibrahim Omer Yahia,Abubakar Mohammed Jibo,Ahmed Yahia Alameer,Elhadi Ibrahim Miskeen,Hatim Khalifa Karar

Online publish date: 29 September 2021

DOI: 10.22514/sv.2021.214

Abstract ( 320 ) PDF (1.92 MB) ( 151 )

Open Access

Utility of inferior vena cava diameter ratio on computed tomography scan among low-risk elderly patients in the emergency department

Sun Hwa Lee,Sung Jin Bae,Keon Kim,Seong Jong Yun,Jong Seok Oh,Ji Yeon Lim

Online publish date: 27 September 2021

DOI: 10.22514/sv.2021.212

Abstract ( 341 ) PDF (473.42 KB) ( 117 )

Special Issues

Special issue title:

Emergency Management of Polytrauma

Keywords: Polytrauma, Trauma, Emergency management, Golden hour, Advanced Trauma Life Support, ABCDE approach, Airway management, cervical spine protection, Glasgow coma scale, hemorrhage, trauma team, survey and management

Editor: Naresh Kaul, MBBS, MD, FICA

Submission deadline: 30 September 2022

Special issue title:

Postoperative analgesia for spine surgery

Keywords: spine surgery, postoperative pain management, multimodal analgesia, opioid, erector spinae plane block, retrolaminar block

Editor: Prof. Joho Tokumine, MD, PhD

Submission deadline: 30 September 2022

Special issue title:

Cardiothoracic anaesthesia and intensive care: current challenges and novelties

Keywords: cardiac anaesthesia, thoracic anaesthesia, intensive care, education, innovation, perioperative medicine, healthcare, outcomes, challenges

Editor: Dr. Marko Zdravkovic, MD, PhD

Submission deadline: 11 March 2022

Special issue title:

Selected papers from Korean Society of Emergency Medicine (KSEM) in 2021-2022

Keywords: Emergency medicine

Editor: Kyungwon Lee, MD, PhD,Young Duck Cho, MD, PhD

Submission deadline: 31 December 2022

Special issue title:

Inter-Professional Teamwork Challenges - intensive care of preterm infants

Keywords: preterm infants, respiratory distress syndrome, severe infection, necrotizing enterocolitis, bronchopulmonary dysplasia, extrauterine growth retardation, hemorrhagic-ischemic cerebral injury, milk protein allergy

Editor: Jinrong Li, MD, PhD,Li-Na Qiao, MD, PhD,Jing Shi, MD, PhD

Submission deadline: 09 June 2022

Special issue title:

Neurocritical care in pandemic and beyond

Keywords: Neurocritical Care, Stroke, Neurotrauma

Editor: Luis Rafael Moscote- Salazar, MD ,Tariq Janjua, MD

Submission deadline: 01 December 2022

Special issue title:

Medical Simulation - success in education, future of science

Keywords: medical simulation, emergency medicine, medical education

Editor: Tomasz Kłosiewicz, MD, MSc,Mateusz Puślecki, PhD

Submission deadline: 31 December 2022

Special issue title:

A patient in a life-threatening condition - challenges and new solutions during the COVID-19 pandemic

Keywords: COVID-19, life-threatening conditions, patient, psychophysical factors, education, simulation, virtual reality

Editor: Paweł Więch, RN, CEN, PhD, DSc

Submission deadline: 30 April 2022

Special issue title:

Fractures in elderly – the ongoing pandemic

Keywords: elderly patients, fragility fractures, mobility, osteosynthesis, joints replacement, periprosthetic fractures, multidisciplinary approach

Editor: Dr. Anze Kristan

Submission deadline: 30 April 2022

Special issue title:

Opioid Sparing Modalities in Perioperative and Critical Care Patients: opioids sparing analgesia pain perioperative

Keywords: Opioid misuse, Prescription opioids, Postsurgical pain, Perioperative strategies, Critical care

Editor: Dr. Michael O’Neil, Pharm.D.

Submission deadline: 28 March 2022

Featured Article

A Novel Objective Approach Towards Physicians' Knowledge and Practice Patterns to Optimize Central Venous Catheter Placement: A Cross-sectional Study. DOI: 10.22514/sv.2020.16.0052

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  2020 has been a very special year, full of events, frequently strange and newly shaped events. As always, humanity has tried to learn from them, searching (and frequently finding) the best solution to the problems. “Work is the best gymnasium where to exercise the intelligence”. This was an excellent definition for “work”. 2020 has obliged anyone to work with new obstacles and to find always new solutions, exercising the intelligence. It is also possible to say that 2020 has provided mankind a fantastic opportunity to express at maximum level its potentialities.

  Between others, I was kindly invited to becoming Editor in Chief of this important journal. Signa Vitae has a nice story, but its aim is to increase its impact in the scientific community. The scientific community deriving from the initial “Anesthesiology”, as it was in the first decades of the twentieth century, in the course of the years has expanded enormously. Now it still covers “Anesthesiology”, but it also covers Emergency, Intensive Cares, Supportive Medicine, and last but not least Pain Medicine. In other terms, the name of the journal, Signa Vitae (“Signs of Life”, with a nuance of Latin classic culture), is extremely appropriate.

  Considering my personal story, the diffusion of Signa Vitae in the field of Pain Medicine will be a natural consequence. The new challenge will definitely be to establish a strong Editorial Board, with Section Editors, and attract high quality papers from the other branch of the medical specialty. For this, the journal counts on the support of most of the Members of the Editorial Board whose story is deeply rooted in Emergency and Intensive Cares.

  The programs for 2021 are incredibly challenging and stimulating. It will be a year of hard work and growth, and the Signa Vitae family is ready to obtain the best possible. I want to take this opportunity to thank the publisher and the Signa Vitae team for their trust in my enthusiasm, inviting me as Editor-in-Chief of a nice and promising journal. Ad majora to all of them and especially to the Authors that will be confident on the potentialities of this journal. Let’s work together for it.

Giustino Varrassi, MD, PhD

Paolo Procacci Foundation, Via Tacito 7, 00193 Roma, Italy