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Original Research

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Effect of prehospital intraosseous combined with in-hospital intravenous access in out-of-hospital cardiac arrest

  • Yan-Wei Cheng1,†
  • Jian-Ge Zhang1,†
  • Xue Cao2
  • Juan Zhu1
  • Li-Jie Qin1

1Department of Emergency, Henan Provincial People′s Hospital, People′s Hospital of Zhengzhou University, People′s Hospital of Henan University, 450000 Zhengzhou, P. R. China

2Department of Rheumatology and Immunology, Henan Provincial People′s Hospital, People′s Hospital of Zhengzhou University, People′s Hospital of Henan University, 450000 Zhengzhou, P. R. China

DOI: 10.22514/sv.2021.046 Vol.17,Issue 6,November 2021 pp.125-130

Submitted: 26 January 2021 Accepted: 20 February 2021

Published: 08 November 2021

*Corresponding Author(s): Li-Jie Qin E-mail:

† These authors contributed equally.


Objective: Obtaining vascular access during out-of-hospital cardiac arrest (OHCA) is challenging. The aim of this study was to compare the effectiveness of prehospital intraosseous infusion (IO) combined with in-hospital intravenous (IV) (pre-IO + in-IV) access versus the simple IV (pre-IV + in-IV) access in adult OHCA patients who do not achieve prehospital return of spontaneous circulation (ROSC).

Methods: This retrospective observational study included adults with OHCA of presumed cardiac etiology between October 1, 2017-October 1, 2020 at an academic emergency department in China. All of the OHCA patients included within the study had Emergency Medical Services cardiopulmonary resuscitation and received prehospital epinephrine administration, but did not achieve prehospital ROSC. The study population were classified as either pre-IO + in-IV or IV (pre-IV + in-IV) based on their epinephrine administration route. The prehospital epinephrine routes were the first and only attempted route. The primary outcome investigated was sustained ROSC following arrival at the emergency department. The secondary outcome considered was the time from dispatch to the first epinephrine dose.

Results: Of 193 included adult OHCA subjects who did not have prehospital ROSC, 128 received IV access only. The 65 pre-IO + in-IV-treated patients received epinephrine faster compared to IV-treated patients in terms of the median time from dispatch to the first injection of epinephrine (14.5 vs. 16.0 min, P = 0.001). In the pre-IO + in-IV group, 34 of 65 patients (52.3%) achieved sustained ROSC compared with 65 of 128 (50.8%) patients in the IV group (χ2 = 0.031, P = 0.841). There was no significant difference in sustained ROSC (adjusted OR1.049, 95% CI: 0.425-2.591, P = 0.918) between the two groups.

Conclusion: A similar sustained ROSC rate was achieved for both the pre-IO + in-IV access group and the simple IV access group. Our results suggested that an IV route should be established quickly for prehospital IO-treated OHCA patients who do not achieve prehospital ROSC.


Out-of-hospital cardiac arrest; Intraosseous; Intravenous; Epinephrine; Return of spontaneous circulation

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Yan-Wei Cheng,Jian-Ge Zhang,Xue Cao,Juan Zhu,Li-Jie Qin. Effect of prehospital intraosseous combined with in-hospital intravenous access in out-of-hospital cardiac arrest. Signa Vitae. 2021. 17(6);125-130.


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