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From preclinical to clinical models of acute respiratory distress syndrome

  • Ruoyang Zhai1
  • Woodys Lenga Ma Bonda1
  • Gustavo Matute-Bello2,3
  • Matthieu Jabaudon1,4

1GReD, Université Clermont Auvergne, CNRS, INSERM, 63000 Clermont-Ferrand, France

2Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA 98105, USA

3Medical Research Service, VA Puget Sound Healthcare System, Seattle, WA 98105, USA

4Department of Perioperative Medicine, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, France

DOI: 10.22514/sv.2021.228

Submitted: 12 August 2021 Accepted: 24 September 2021

Online publish date: 10 November 2021

*Corresponding Author(s): Matthieu Jabaudon E-mail: mjabaudon@chu-clermontferrand.fr

Abstract

Various preclinical models that mimic the clinical causes of acute respiratory distress syndrome (ARDS) have been used to better understand the mechanisms of acute lung injury and its repair and to investigate novel therapies targeting such mechanisms. Despite important preclinical and clinical research efforts in recent decades, few candidate therapies with promising preclinical effects have been successfully translated into the clinical scenario, which could be attributable to the intrinsic limitations of the models as well as to the incorrect identification of appropriate phenotypes of patients to target with novel therapies that have proven beneficial in select preclinical models. However, current translational research strategies based on the use of multiple complementary preclinical and clinical models hold the promise of revolutionizing intensive care by using granular knowledge that should allow for a better diagnosis, greater predictability of the disease course, and the development of targeted therapies while ensuring patient safety through reduced adverse effects. Our goal was to summarize the strengths and limitations of the available models of ARDS, including animal, in vitro, and clinical models, and to discuss the current challenges and perspectives for research.


Keywords

Acute respiratory distress syndrome; Acute lung injury; Preclinical models; Transla-tional research


Cite and Share

Ruoyang Zhai,Woodys Lenga Ma Bonda,Gustavo Matute-Bello,Matthieu Jabaudon. From preclinical to clinical models of acute respiratory distress syndrome. Signa Vitae. 2021.doi:10.22514/sv.2021.228.

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Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 0.5(2019) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

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