Article Data

  • Views 262
  • Dowloads 140

Meeting Abstracts

Open Access

Precision Medicine in migraine management

  • Theodora Barkoula1

1Neurological Clinic, General Oncology Hospital, "Agioi Anargyroi", Athens, Greece

DOI: 10.22514/sv.2021.206 Vol.17,Issue S1,September 2021 pp.64-64

Submitted: 26 August 2021 Accepted: 06 September 2021

Published: 15 September 2021

*Corresponding Author(s): Theodora Barkoula E-mail: dora.bark@gmail.com

Abstract

Migraine is a common disorder that negatively affects a significant percentage of patients, with corresponding social and economic costs. It is a neurovascular disease whose pathophysiological mechanisms are still being examined. While cortical spreading depression (CSD) and dysfunction of the trigeminovascular system appear to play a key role in the onset of migraine aura and pain, the study of human genome has shown the involvement of several genes and neuropeptides in its pathogenesis. New data make it necessary to search for targeted methods in the diagnosis and treatment of the disease, as current therapeutic approaches in many cases show little effectiveness and significant side effects.

Nowadays, the rapid development of genetics opens new horizons in the approach of migraine through the prism of Medical Precision. Precision Medicine (PM) is a new approach to the treatment and prevention of the disease, which combines the individualized approach of the patient with the design and implementation of appropriate treatment. It differs radically from the "one size fits all" approach, leading to a better understanding of the pathophysiological mechanisms of the disease and the development of innovative diagnostic and treatment options. It combines the expression of genome and the correlation of science of Biochemistry with the comorbidity of the patient, in order to achieve the optimal clinical result.

The purpose of this essay is to present the current therapeutic approaches for migraine treatment and to investigate their applicability, according to the new data of Medical Precision. The investigation and identification of new genetic, epigenetic, biochemical and other biomarkers will enable the patient to be better approached, more targeted treatment and reduced disease’s management costs.


Keywords

redMigraine; Precision medicine; Biomarkers; Genome; Neuropeptides; Genetics; Therapy


Cite and Share

Theodora Barkoula. Precision Medicine in migraine management. Signa Vitae. 2021. 17(S1);64-64.

References

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

IndexCopernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 0.5(2019) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time

Conferences

Top