Article Data

  • Views 266
  • Dowloads 136

Original Research

Open Access

Thiol disulfide homeostasis in primary dysmenorrhea

  • Atakan Savrun1
  • Şeyda Tuba Savrun1
  • Ebubekir Dirican2
  • Emre Gökçen3
  • Yeliz Kasko Arıcı4
  • Ali Aygün1
  • Vakkas Korkmaz5
  • Salim Neşelioğlu6
  • Özcan Erel6
  • Tuğba Raika Kıran7

1Department of Emergency Medicine, Ordu University Faculty of Medicine, 52100 Ordu, Turkey

2Health Services Vocational School, Bayburt University, 69010 Bayburt, Turkey

3Department of Emergency Medicine, Bozok University Faculty of Medicine, 66100 Yozgat, Turkey

4Department of Biostatistics and Medical Informatics, Ordu University Faculty of Medicine, 52100 Ordu, Turkey

5Ankara Doctor Zekai Tahir Burak Women Health Educatıon And Research Hospıtal Gynecologic Oncology Surgery, 06730 Ankara, Turkey

6Department of Medical Biochemistry, Faculty of Medicine, Yıldırım Beyazıt University, 06760 Ankara, Turkey

7Department of Biomedical Engineering, Iskenderun Technical University, 31300 Iskenderun, Turkey

DOI: 10.22514/sv.2021.151

Submitted: 21 June 2021 Accepted: 10 August 2021

Online publish date: 13 September 2021

*Corresponding Author(s): Atakan Savrun E-mail: atakan4601@hotmail.com
*Corresponding Author(s): Ebubekir Dirican E-mail: dr.diricanebubekir@gmail.com

Abstract

Oxidative stress is defined as a result of the loss of balance between the production of free radical or reactive oxygen species and the antioxidant system. This study aimed to determine the level of thiol-disulfide homeostasis (TDH) in the serum of women with primary dysmenorrhea. The study group consisted of 42 subjects with primary dysmenorrhea, and the control group consisted of 30 volunteer women with demographic characteristics similar to the study group. Native thiol (SH), total thiol (TSH), disulphide (SS), and SH/SS parameters were measured for TDH of the subjects. The SH (p = 0.038) and SH/TSH (p = 0.046) levels were significantly higher while SS (p = 0.013), SS/SH (p = 0.042) and SS/TSH (p = 0.046) levels were lower in the study group than in the healthy control group. The SS cut-off value was determined as 17.85 in the study group (sensitivity = 61.9%, specificity = 43.3%). Therefore, the probability of dysmenorrhea may increase significantly when SS levels fall below this value. In subjects with dysmenorrhea, there was a decrease in SS levels and an increase in SH levels in order to protect the cells and tissues from the harmful effects of free radicals.


Keywords

Primary dysmenorrhea; Thiol-disulfide; Oxidative stress; ROC analysis; TDH


Cite and Share

Atakan Savrun,Şeyda Tuba Savrun,Ebubekir Dirican,Emre Gökçen,Yeliz Kasko Arıcı,Ali Aygün,Vakkas Korkmaz,Salim Neşelioğlu,Özcan Erel,Tuğba Raika Kıran. Thiol disulfide homeostasis in primary dysmenorrhea. Signa Vitae. 2021.doi:10.22514/sv.2021.151.

References

[1] Karabulut H, Gülay MŞ. Serbest Radikaller Free Radicals. Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi. 2016; 4: 50–59.

[2] Fang Y, Yang S, Wu G. Free radicals, antioxidants, and nutrition. Nutrition. 2002; 18: 872–879.

[3] Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clinical Biochemistry. 2014; 47: 326–332.

[4] Eren Y, Dirik E, Neşelioğlu S, Erel Ö. Oxidative stress and decreased thiol level in patients with migraine: cross-sectional study. Acta Neurologica Belgica. 2015; 115: 643–649.

[5] Sönmez MG, Kozanhan B, Deniz ÇD, Göger YE, Kılınç MT, Neşeliogˇlu S, et al. Is oxidative stress measured by thiol/disulphide homeostasis status associated with prostate adenocarcinoma? Central European Journal of Immunology. 2018; 43: 174–179.

[6] Turkyilmaz E, Yildirim M, Cendek BD, Baran P, Alisik M, Dalgaci F, et al. Evaluation of oxidative stress markers and intra-extracellular antioxidant activities in patients with endometriosis. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2016; 199: 164–168.

[7] Bernardi M, Lazzeri L, Perelli F, Reis FM, Petraglia F. Dysmenorrhea and related disorders. F1000Research. 2017; 6: 1645.

[8] Omani Samani R, Almasi Hashiani A, Razavi M, Vesali S, Rezaeinejad M, Maroufizadeh S, et al. The prevalence of menstrual disorders in Iran: a systematic review and meta-analysis. International Journal of Reproductive Biomedicine. 2018; 16: 665–678.

[9] Jiang Z, Wang J, Guo X, Feng L, Yu M, Zhou J, et al. Menstrual disorders and occupational exposures among female nurses: a nationwide cross-sectional study. International Journal of Nursing Studies. 2019; 95: 49–55.

[10] Silva GD, Canova NAH, Bortoletto P, Wutzke MLS, Soares F dos S, Bertolini GRF. Cryotherapy Produces Pain Relief in Young People with Primary Dysmenorrhea. Therapeutic Hypothermia and Temperature Management. 2021. (in press)

[11] Harada T. Dysmenorrhea and endometriosis in young women. Yonago Acta Medica. 2013; 56: 81–84.

[12] Yuan L, Lin D, Kang X, Ye Y. Shaofu Zhuyu decoction for primary dysmenorrhea. Medicine. 2021; 100: e26226.

[13] Morrow C, Naumburg EH. Dysmenorrhea. Primary Care. 2009; 36: 19–32.

[14] Liu Y, Yao L, Yan B, Jiang H, Zhao J, Cao J, et al. The effectiveness of acupoint application of traditional Chinese medicine in treating primary dysmenorrhea. Medicine. 2021; 100: e26398.

[15] Evans S, Dowding C, Olive L, Payne LA, Druitt M, Seidman LC, et al. Pain catastrophizing, but not mental health or social support, is associated with menstrual pain severity in women with dysmenorrhea: A cross-sectional survey. Psychology, Health & Medicine. 2021. (in press)

[16] Dawood MY. Primary dysmenorrhea: advances in pathogenesis and management. Obstetrics and Gynecology. 2006; 108: 428–441.

[17] Turhan N, Celik H, Duvan Cİ, Onaran Y, Aydın M, Armutcu F. Investigation of oxidative balance in patients with dysmenorrhea by multiple serum markers. Journal of the Turkish German Gynecological Association. 2012; 13: 233–236.

[18] Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, et al. Oxidative Stress: Harms and Benefits for Human Health. Oxidative Medicine and Cellular Longevity. 2017; 2017: 8416763.

[19] Dikensoy E, Balat O, Pençe S, Balat A, Cekmen M, Yurekli M. Malondialdehyde, nitric oxide and adrenomedullin levels in patients with primary dysmenorrhea. Journal of Obstetrics and Gynaecology Research. 2008; 34: 1049–1053.

[20] Szmidt MK, Granda D, Sicinska E, Kaluza J. Primary Dysmenorrhea in Relation to Oxidative Stress and Antioxidant Status: A Systematic Review of Case-Control Studies. Antioxidants. 2020; 9: 994.

[21] Adeyemi A, Adekanle D. Management Of Dysmenorrrhoea Among Medical Students. The Internet Journal of Gynecology and Obstetrics. 2007; 7.

[22] Korkmaz V, Kurdoglu Z, Alisik M, Cetin O, Korkmaz H, Surer H, et al. Impairment of thiol-disulfide homeostasis in preeclampsia. Journal of Maternal-Fetal & Neonatal Medicine. 2016; 29: 3848–3853.

[23] Larroy C. Comparing visual-analog and numeric scales for assessing menstrual pain. Behavioral Medicine. 2002; 27: 179–181.

[24] Akdemir N, Cinemre FB, Bostancı MS, Cinemre H, Ünal O, Ozden S, et al. The correlation of serum asymmetric dimethylarginine and anti-Müllerian hormone in primary dysmenorrhea. The Kaohsiung Journal of Medical Sciences. 2016; 32: 414–419.

[25] Trotta E, Bortolotti S, Fugazzotto G, Gellera C, Montagnese S, Amodio P. Familial vitamin E deficiency: Multiorgan complications support the adverse role of oxidative stress. Nutrition. 2019; 63-64: 57–60.

[26] Atmaca G. Antioxidant effects of sulfur-containing amino acids. Yonsei Medical Journal. 2004; 45: 776–788.

[27] Parcell S. Sulfur in human nutrition and applications in medicine. Alternative Medicine Review. 2002; 7: 22–44.

[28] Kelly GS. Clinical applications of N-acetylcysteine. Alternative Medicine Review : a Journal of Clinical Therapeutic. 1998; 3: 114–127.

[29] Yeh M, Chen H, So EC, Liu C. A study of serum malondialdehyde and interleukin-6 levels in young women with dysmenorrhea in Taiwan. Life Sciences. 2004; 75: 669–673.

[30] Kaplan Ö, Nazıroğlu M, Güney M, Aykur M. Non-steroidal anti-inflammatory drug modulates oxidative stress and calcium ion levels in the neutrophils of patients with primary dysmenorrhea. Journal of Reproductive Immunology. 2013; 100: 87–92.

[31] Menteşe Ü, Turan İ, Doğan S, Sümer A, Coşkun C, Alver A, et al. Evaluation of oxidative stress balance in acute deep vein thrombosis. Turkish Journal of Biochemistry. 2015; 40: 51–57.


Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

IndexCopernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 0.5(2019) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time

Conferences

Top