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Original Research

Open Access

Topical 5% lidocaine patches for treating postherpetic neuralgia: a survey among nurses and patients

  • Joseph V. Pergolizzi Jr.1
  • Sri Nalamachu2
  • Kailyn Mitchell1
  • Antonella Paladini3
  • Robert Taylor Jr.1
  • Giustino Varrassi1,4

1NEMA Research Inc., 868 106th Ave North, Naples, FL 34108, USA

2Mid-America Poly Clinic, 7100 College Boulevard, Overland Park, Overland Park, KS 66210, USA

3Department of MESVA, University of L’Aquila, 67100 L’Aquila, Italy

4Paolo Procacci Foundation, Via Tacito 7, 00193 Roma, Italy

DOI: 10.22514/sv.2021.114

Submitted: 18 January 2021 Accepted: 18 May 2021

Online publish date: 29 June 2021

*Corresponding Author(s): Robert Taylor Jr. E-mail: rtaylor@nemaresearch.com robert.taylor.phd@gmail.com

Abstract

Introduction: Postherpetic neuralgia (PHN) is associated with moderate to severe pain with peripheral and central mechanisms. While there is no clear-cut first-line therapeutic approach to PHN pain control, lidocaine patches are frequently used as monotherapy or part of a multimodal pain regimen.

Methods: An online survey, the first of its kind, was conducted among PHN patients (n = 153) and nurses (n = 151) in order to determine clinical and patient knowledge, attitudes and practices toward the lidocaine patch and current unmet needs.

Results: Results of the survey indicated that PHN patients are prescribed a mean of 2.6 medications to control their PHN pain, including the lidocaine patch. There were negative responses related to the patches’ ability to adhere to the skin. Patients reported the use of tape to hold the patches in place and/or patches that detached completely, truncating the therapeutic dose period. Most nurses (53%) found the biggest obstacle to PHN pain control was noncompliance and 98% stated that reliable patch adhesion for the intended 12-hour application was “somewhat important” or “very important” for PHN pain control. Forty-five percent of nurses said that poor patient adherence to PHN analgesic regimens was related to poor adhesion of the lidocaine patch.

Conclusion: A new bioequivalent lidocaine patch has been developed with better adhesive characteristics, nine-fold greater bioavailability, and improved form factor.


Keywords

Post-herpetic neuralgia; Lidocaine patch; Survey; Nurses; Pain; Quality of life; Daily living


Cite and Share

Joseph V. Pergolizzi Jr.,Sri Nalamachu,Kailyn Mitchell,Antonella Paladini,Robert Taylor Jr.,Giustino Varrassi. Topical 5% lidocaine patches for treating postherpetic neuralgia: a survey among nurses and patients. Signa Vitae. 2021.doi:10.22514/sv.2021.114.

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