Article Data

  • Views 608
  • Dowloads 175

Original Research

Open Access Special Issue

Polydipsia-polyuria syndrome associated with traumatic spinal cord injury

  • Cristina Daia1,2
  • Constantin Munteanu3,4,5
  • Ioana Andone1,2
  • Aura Spinu1,2
  • Cristina Popescu1,2
  • Corneliu Toader6,7
  • Gelu Onose1,2,4

1Department of Medical Rehabilitation, University of Medicine and Pharmacy “Carol Davila”, 4192910 Bucharest, Romania

2Neuromuscular Department, Clinical Emergency Hospital “Bagdasar-Arseni”, 041914 Bucharest, Romania

3Department of Research, Romanian Association of Balneology, 022252 Bucharest, Romania

4Physical and Rehabilitation Medicine & Balneology Research Nucleus, Clinical Emergency Hospital “Bagdasar-Arseni”, 041914 Bucharest, Romania

5Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa”,700454 Iași, Romania

6Department of Neurosurgery, “Carol Davila”, University of Medicine and Pharmacy, 041914 Bucharest, Romania

7Neurosurgery Department, National Institute of Cerebro-Vascular Diseases, 041914 Bucharest, Romania

DOI: 10.22514/sv.2021.104 Vol.17,Issue 6,November 2021 pp.74-81

Submitted: 23 March 2021 Accepted: 19 May 2021

Published: 08 November 2021

*Corresponding Author(s): Constantin Munteanu E-mail: constantin2378@yahoo.com

Abstract

Introduction: Polydipsia and polyuria associated with traumatic spinal cord injury (SCI) are rare consequences. The hypothetical pathophysiological mechanisms involve mild traumatic brain injury (TBI) and/ or vagus dysfunction associated with spinal cord injury.

Methods: In a retrospective study of 11 patients, we investigated associations between polydipsia-polyuria syndrome and various clinical and therapeutic factors: medullary section syndrome, neurological level, medication, neurosurgical intervention, kinesitherapy program, associated comorbidities, functional level at discharge and patient quality of life (QoL).

Results: The beginning of the kinetic program (Spearman correlation coefficient =0.631) and desmopressin treatment (Spearman correlation coefficient =0.708) had statistically significant effects on resolution of polydipsia-polyuria syndrome (PPS). Patient QoL was statistically significant improved after resolution of PPS (t-test, p =0.001).

Conclusions: Mobilization programs appear to promote resolution of PPS. Desmo-pressin treatment is beneficial and, together, medication and kinesitherapy elevate patients’ QoL. The association between SCI and transient PPS requires additional investigation in additional patients.


Keywords

Polyuria; Polydipsia; Spinal cord injury


Cite and Share

Cristina Daia,Constantin Munteanu,Ioana Andone,Aura Spinu,Cristina Popescu,Corneliu Toader,Gelu Onose. Polydipsia-polyuria syndrome associated with traumatic spinal cord injury. Signa Vitae. 2021. 17(6);74-81.

References

[1] Farrell CA, Staas WE Jr. Diabetes insipidus in a quadriplegic patient. Archives of Physical Medicine and Rehabilitation. 1986; 67: 132–134.

[2] Prasad V, Raju B, Dinakar I, Dinkar I. Diabetes insipidus in cervico-dorsal spinal cord injury. Neurology India. 1995; 43: 206–208.

[3] Kuzeyli K, Çakr E, Baykal S, Karaarslan G. Diabetes insipidus secondary to penetrating spinal cord trauma: case report and literature review. Spine. 2001; 26: E510–E511.

[4] Closson BL, Beck LA, Swift MA. Diabetes insipidus and spinal cord injury: a challenging combination. Rehabilitation Nursing. 1993; 18: 368–374.

[5] Lude P, Kennedy P, Elfström ML, Ballert CS. Quality of Life in and after Spinal Cord Injury Rehabilitation: a Longitudinal Multicenter Study. Topics in Spinal Cord Injury Rehabilitation. 2014; 20: 197–207.

[6] Makaryus AN, McFarlane SI. Diabetes insipidus: diagnosis and treatment of a complex disease. Cleveland Clinic Journal of Medicine. 2006; 73: 65–71.

[7] Ohbuchi T, Haam J, Tasker JG. Regulation of Neuronal Activity in Hypothalamic Vasopressin Neurons. Interdisciplinary Information Sciences. 2015; 21: 225–234.

[8] Gormally JF, Izard MA, Robinson BG, Boyle FM. Pituitary metastasis from breast cancer presenting as diabetes insipidus. British Medical Journal Case Reports. 2014; 2014: bcr2014203683.

[9] Decanter C, Hober C, Hamon M, Lafitte JJ, Lefebvre J, Vantyghem MC. Diabetes insipidus revealing pituitary metastasis of bronchial carcinoma. Annales D’Endocrinologie. 1996; 57: 411–417. (In French)

[10] Jain S, Iverson LM. Glasgow Coma Scale. Treasure Island: StatPearls Publishing. 2021.

[11] Laczi F. Diabetes insipidus: etiology, diagnosis, and therapy. Orvosi Hetilap. 2002; 143: 2579–2585. (In Hungarian)

[12] Roberts TT, Leonard GR, Cepela DJ. Classifications in Brief: Amer-ican Spinal Injury Association (ASIA) Impairment Scale. Clinical Orthopaedics and Related Research. 2017; 475: 1499–1504.

[13] Burckhardt CS, Anderson KL, Archenholtz B, Hägg O. The Flanagan Quality of Life Scale: evidence of construct validity. Health and Quality of Life Outcomes. 2003; 1: 59.

[14] Kidd D, Stewart G, Baldry J, Johnson J, Rossiter D, Petruckevitch A, et al. The Functional Independence Measure: a comparative validity and reliability study. Disability and Rehabilitation. 1995; 17: 10–14.

[15] McCarty TS, Shah AD. Desmopressin. Treasure Island: StatPearls Publishing. 2021.

[16] O’Neil ME, Carlson K, Storzbach D, Brenner L, Freeman M, Quiñones A, et al. Complications of Mild Traumatic Brain Injury in Veterans and Military Personnel: A Systematic Review. Washington: Department of Veterans Affairs (US). 2013.

[17] Diederich S, Eckmanns T, Exner P, Al-Saadi N, Bähr V, Oelkers W. Differential diagnosis of polyuric/polydipsic syndromes with the aid of urinary vasopressin measurement in adults. Clinical Endocrinology. 2001; 54: 665–671.

[18] Oz B, Olmez N, Memis A, Oruk G. Differential Diagnosis of Polyuria and Polydipsia in a Patient with Spinal Cord Injury. American Journal of Physical Medicine & Rehabilitation. 2005; 84: 817–820.

[19] Malve H, Kalra S, Zargar AH, Jain SM, Sethi B, Chowdhury S, et al. Diabetes insipidus: the other diabetes. Indian Journal of Endocrinology and Metabolism. 2016; 20: 9–21.

[20] Yasir M, Mechanic OJ. Syndrome of Inappropriate Antidiuretic Hormone Secretion. Treasure Island: StatPearls Publishing. 2021.

[21] Esposito P, Piotti G, Bianzina S, Malul Y, Dal Canton A. The syndrome of inappropriate antidiuresis: pathophysiology, clinical management and new therapeutic options. Nephron Clinical Practice. 2011; 119: c62–c73.

[22] Tenny S, Thorell W. Cerebral Salt Wasting Syndrome. Treasure Island: StatPearls Publishing. 2021.

[23] Spinal cord injury facts and figures at a glance. The Journal of Spinal Cord Medicine. 2012; 35:197–198.

[24] Kenny BJ, Bordoni B. Neuroanatomy, Cranial Nerve 10 (Vagus Nerve). Treasure Island: StatPearls Publishing. 2021.

[25] Nozaki A, Ando T, Akazawa S, Satoh T, Sagara I, Horie I, et al. Quality of life in the patients with central diabetes insipidus assessed by Nagasaki Diabetes Insipidus Questionnaire. Endocrine. 2016; 51: 140–147.

[26] Frisbie JH. Salt wasting, hypotension, polydipsia, and hyponatremia and the level of spinal cord injury. Spinal Cord. 2007; 45: 563–568.

[27] Juul KV, Malmberg A, van der Meulen E, Walle JV, Nørgaard JP. Low-dose desmopressin combined with serum sodium monitoring can prevent clinically significant hyponatraemia in patients treated for nocturia. British Journal of Urology International. 2017; 119: 776–784.

[28] Bauman WA, Wecht JM, Biering-Sørensen F. International spinal cord injury endocrine and metabolic extended data set. Spinal Cord. 2017; 55: 466–477.

[29] Brämer GR. International statistical classification of diseases and related health problems. Tenth revision. World Health Statistics Quarterly. 1988; 41: 32–36.

[30] Sitprija V, Pochanugool C, Benyajati C, Suwanwela C. Polydipsia and polyuria associated with quadriplegia. Annals of Internal Medicine. 1966; 65: 62–68.



Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

IndexCopernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 0.5(2019) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time

Conferences

Top