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Severe invasive disease caused by hypervirulent Klebsiella pneumoniae: a case report

  • Qingdong Li1
  • Yongli Zhang1

1Department of Critical Care Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, P. R. China

DOI: 10.22514/sv.2021.052

Online publish date: 23 March 2021

*Corresponding Author(s): Yongli Zhang E-mail: zylicu@163.com

Abstract

Klebsiella pneumoniae (K. pneumoniae) is a common pathogenic bacteria that causes numerous infectious diseases. Hypervirulent K. pneumoniae (hvKP) can lead to invasive K. pneumoniae liver abscess syndrome, which can induce life-threatening multiple organ dysfunction syndrome or septic shock. We report a case of invasive K. pneumoniae liver abscess syndrome caused by hvKP and discuss the treatment options of this syndrome. Appropriate antimicrobial drugs should be administered to improve prognosis and prevent complications, and laboratory testing is essential to guide clinical management and optimize patient outcomes.


Keywords

Hypervirulent Klebsiella pneumonia; Antimicrobial therapy; Prognosis; Case report


Cite and Share

Qingdong Li,Yongli Zhang. Severe invasive disease caused by hypervirulent Klebsiella pneumoniae: a case report. Signa Vitae. 2021.doi:10.22514/sv.2021.052.

References

[1] Qian Y, Wong CC, Lai S, Chen H, He X, Sun L, et al. A retrospective study of pyogenic liver abscess focusing on Klebsiella pneumoniae as a primary pathogen in China from 1994 to 2015. Scientific Reports. 2016; 6: 38587.

[2] Lee H, Chuang Y, Yu W, Lee N, Chang C, Ko N, et al. Clinical implications of hypermucoviscosity phenotype in Klebsiella pneumoniae isolates: association with invasive syndrome in patients with community-acquired bacteraemia. Journal of Internal Medicine. 2006; 259: 606-614.

[3] Zhang Y, Zhao C, Wang Q, Wang X, Chen H, Li H, et al. High prevalence of hypervirulent Klebsiella pneumoniae infection in China: geographic distribution, clinical characteristics, and antimicrobial resistance. Antimi-crobial Agents and Chemotherapy. 2016; 60: 6115-6120.

[4] Van Keer J, Van Keer K, Van Calster J, Derdelinckx I. More than meets the eye: Klebsiella pneumoniae invasive liver abscess syndrome presenting with endophthalmitis. The Journal of Emergency Medicine. 2017; 52: e221-e223.

[5] Namikawa H, Yamada K, Fujimoto H, Oinuma K, Tochino Y, Takemoto Y, et al. Two unusual cases of successful treatment of hypermucoviscous Klebsiella pneumoniae invasive syndrome. BMC Infectious Diseases. 2016; 16: 680.

[6] Guo Y, Wang S, Zhan L, Jin Y, Duan J, Hao Z, et al. Microbiological and clinical characteristics of hypermucoviscous Klebsiella pneumoniae isolates associated with invasive infections in China. Frontiers in Cellular and Infection Microbiology. 2017; 7: 24.

[7] Wang B, Zhang P, Li Y, Wang Y. Klebsiella pneumoniae-induced multiple invasive abscesses. Medicine. 2019; 98: e17362.

[8] Bradley ME, Scoular SK. Metastatic Klebsiella pneumoniae invasive liver abscess syndrome in Denver, Colorado. Journal of Pharmacy Practice. 2019; 897190019882867.

[9] Martin RM, Bachman MA. Colonization, infection, and the accessory genome of Klebsiella pneumoniae. Frontiers in Cellular and Infection Microbiology. 2018; 8: 4.

[10] Struve C, Roe CC, Stegger M, Stahlhut SG, Hansen DS, Engelthaler DM, et al. Mapping the evolution of hypervirulent Klebsiella pneumoniae. MBio. 2015; 6: e00630.

[11] Siu LK, Yeh K, Lin J, Fung C, Chang F. Klebsiella pneumoniae liver abscess: a new invasive syndrome. The Lancet Infectious Diseases. 2012; 12: 881-887.

[12] Hyun M, Lee JY, Ryu S, Ryoo N, Kim HA. Antibiotic resistance and clinical presentation of health care-associated hypervirulent Klebsiella pneumoniae infection in Korea. Microbial Drug Resistance. 2019; 25: 1204-1209.

[13] Ge F, Parker J, Chul Choi S, Layer M, Ross K, Jilly B, et al. Preferential amplification of pathogenic sequences. Scientific Reports. 2015; 5: 11047.

[14] Chew KL, Lin RTP, Teo JWP. Klebsiella pneumoniae in Singapore: hypervirulent Infections and the Carbapenemase threat. Frontiers in Cellular and Infection Microbiology. 2017; 7: 515.

[15] Siu LK, Yeh K, Lin J, Fung C, Chang F. Klebsiella pneumoniae liver abscess: a new invasive syndrome. The Lancet. Infectious Diseases. 2012; 12: 881-887.

[16] Sturm E, Tai A, Lin B, Kwong J, Athan E, Howden BP, et al. Bilateral osteomyelitis and liver abscess caused by hypervirulent Klebsiella pneumoniae- a rare clinical manifestation (case report). BMC Infectious Diseases. 2018; 18: 380.

[17] Setsu T, Tsuchiya A, Yamagiwa S, Terai S. Invasive liver abscess syndrome caused by Klebsiella pneumoniae. Internal Medicine. 2017; 56: 3121-3122.

[18] Chen Y, Li Y, Lin Y, Chen Y, Wang N, Chao A, et al. Prognostic factors and visual outcomes of pyogenic liver abscess-related endogenous Klebsiella pneumoniae endophthalmitis: a 20-year retrospective review. Scientific Reports. 2019; 9: 1071.

[19] Li Y, Chen Y, Chen K, Wang N, Sun M, Chao A, et al. Infectious sources, prognostic factors, and visual outcomes of endogenous Klebsiella pneumoniae endophthalmitis. Ophthalmology Retina. 2018; 2: 771-778.

[20] Chen S, Lee Y, Chen Y, Lin H, Wu T, Sheu S. Klebsiella pneumoniae infection leads to a poor visual outcome in endogenous endophthalmitis: a 12-year experience in southern Taiwan. Ocular Immunology and Inflammation. 2017; 25: 870-877.


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