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On the potential effect of circadian rhythms of cardiac troponins on the diagnosis of acute myocardial infarction

  • Aleksey Michailovich Chaulin1
  • Dmitry V. Duplyakov1

1Department of Cardiology and Cardiovascular Surgery, Samara State Medical University, Chapaevskaya Str. 89, 443099 Samara, Russia

DOI: 10.22514/sv.2021.050 Vol.17,Issue 3,May 2021 pp.79-84

Submitted: 01 February 2021 Accepted: 23 February 2021

Published: 08 May 2021

*Corresponding Author(s): Aleksey Michailovich Chaulin E-mail:


Methods for the determination of cardiac troponins have been significantly improved, facilitating further advancement of the therapeutic and diagnostic process of the cardiovascular diseases case management. In particular, acceleration of the acute myocardial infarction testing (early diagnostic algorithms: 0-1 h, 0-3 h) enabled earlier detection and choice of the optimal treatment tactics. At the same time, with the increased sensitivity in the laboratory test results interpretation, there emerged a necessity to take into account some additional factors that may affect the concentration of cardiac troponins in blood serum. Several recent studies have reported the existence of circadian rhythms in cardiac troponins. This article aims to discuss the possible mechanisms of how circadian rhythms of cardiac troponins develop and their influence on the diagnosis of acute myocardial infarction.


Cardiac troponins; Cardiovascular diseases; Acute myocardial infarction; Circadian rhythms; High-sensitive analyses

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Aleksey Michailovich Chaulin,Dmitry V. Duplyakov. On the potential effect of circadian rhythms of cardiac troponins on the diagnosis of acute myocardial infarction. Signa Vitae. 2021. 17(3);79-84.


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