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Original Research

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Recovery from acute kidney injury is an independent predictor of survival at 30 days only after out-of-hospital cardiac arrest who were treated by targeted temperature management

  • Kyoung-Chul Cha1,†
  • In Soo Cho2,†
  • Je Hyeok Oh3,†
  • Yoo Seok Park4
  • Yoon Hee Choi5
  • Sun Ju Kim1
  • Tae Youn Kim1

1Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea

2Department of Emergency Medicine, Hanil General Hospital, Seoul, Republic of Korea

3Department of Emergency Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea

4Department of Emergency Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea

5Department of Emergency Medicine, Ewha Womans University Medical Center and Ewha Womans University Mokdong Hospital, Seoul, Republic of Korea

DOI: 10.22514/sv.2021.011 Vol.17,Issue 2,March 2021 pp.119-126

Published: 08 March 2021

*Corresponding Author(s): In Soo Cho E-mail: mensa@hanmail.net
*Corresponding Author(s): Je Hyeok Oh E-mail: jehyeokoh@cau.ac.kr

† These authors contributed equally.

Abstract

Background: Development of acute kidney injury (AKI) after out-of-hospital cardiac arrest (OHCA) is associated with mortality and poor neurological outcome. However, the effect of recovery from AKI after OHCA is uncertain. This study investigates whether recovery from AKI was associated with the rate of survival and neurological outcome at 30 days after OHCA.

Methods: This is a prospective multicentre observational cohort study of adult OHCA patients treated with targeted temperature management (TTM) across five hospitals in South Korea between February 2019 and July 2020. AKI was diagnosed using the Kidney Disease: Improving Global Outcomes criteria. The primary outcome was the rate of survival at 30 days, and the secondary outcome was the rate of survival with a favourable neurological outcome at 30 days, defined by a score of 3 or less on the modified Rankin scale.

Results: Among the 2,018 patients with OHCA, 79 were treated with TTM. After excluding two patients with incomplete data on outcomes, 77 were analysed. AKI developed in 43 (56%) patients. Among them, 22 (51%) recovered from AKI. Although the rate of survival at 30 days for the recovery group was superior to the non-recovery group (82% vs. 24%, P < 0.001), the rate of survival with a favourable neurological outcome at 30 days for the recovery group was not different than that for the non-recovery group (32% vs. 10%, P = 0.132). Recovery from AKI was an independent predictor of survival at 30 days after OHCA in the multivariate analysis (adjusted odds ratio, 22.737; 95% confidence interval, 3.814-135.533; P = 0.001); however, it was not associated with a favourable neurological outcome at 30 days after OHCA in the multivariate analysis.

Conclusion: Recovery from AKI was an independent predictor of survival at 30 days only after OHCA who were treated by TTM.


Keywords

Acute kidney injury; Out-of-hospital cardiac arrest; Targeted temperature management; Therapeutic hypothermia


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Kyoung-Chul Cha,In Soo Cho,Je Hyeok Oh,Yoo Seok Park,Yoon Hee Choi,Sun Ju Kim,Tae Youn Kim. Recovery from acute kidney injury is an independent predictor of survival at 30 days only after out-of-hospital cardiac arrest who were treated by targeted temperature management. Signa Vitae. 2021. 17(2);119-126.

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