Pharmacological Interventions for Post-operative Sore Throat (POST): A Network Meta-analysis
1Department of Critical care, King Saud University Medical City, King Saud University, Riyadh , Saudi Arabia
2Critical care department, Wollongong public hospital, Loftus street, Wollongong, New South Wales, Australia
3Department of Critical care, King Khalid University Hospital, King Saud University Medical city, Riyadh, Saudi Arabia
4Lecturer at King Saud University department of Pathology, Microbiology unit, Riyadh, Saudi Arabia
DOI: 10.22514/sv.2020.16.0085 Vol.17,Issue 1,January 2021 pp.169-177
Published: 08 January 2021
Background: To study the efficacy of current post-extubation pharmacologic treatments for postoperative sore throat (POST) prevention. Method: We searched nine databases for randomized controlled trials (RCTs) assessing the efficacy of post-extubation treatments in POST prevention. A network meta-analysis was used to pool the results. Results: Of the 124 records screened, we included 13 studies with 1820 patients. Ketorolac tromethamine was found to be the most effective with the lowest POST rates (P-score = 0.99), followed by ketamine (P-score = 0.68), amyl-m-cresol (P-score = 0.67), flurbiprofen (P-score = 0.66), benzydamine hydrochloride (P-score = 0.62), magnesium (P-score = 0.33), dexamethasone (P-score = 0.30), and lidocaine (P-score = 0.07). Moreover, the following treatments were found to be significantly effective in reducing POST in comparison to control/placebo treatment: ketorolac tromethamine (OR = 0.11; [95% CI=0.05 – 0.21]) followed by ketamine (OR = 0.32; [95% CI = 0.17 – 0.62]), amyl-m-cresol (OR = 0.32; [95% CI = 0.14 – 0.73]), flurbiprofen (OR = 0.33;[95% CI = 0.13 – 0.81]), and benzydamine hydrochloride (OR = 0.36; [95% CI = 0.24 –0.54]). Conclusion: Ketorolac tromethamine, ketamine, amyl-m-cresol, flurbiprofen, and benzydamine hydrochloride were found to be significantly effective in reducing POST. Moreover, ketorolac tromethamine was the most effective and significantly better than all other treatments in reducing POST rates.
Sore throat, Prevention, Systematic review
Rakan M. AlQahtani,Mohyeldin Abdalla,Yamen Hassan Azzam,Ahmed AbdElhamed Elsherif,Raed Ibrahim Altulayhi. Pharmacological Interventions for Post-operative Sore Throat (POST): A Network Meta-analysis. Signa Vitae. 2021. 17(1);169-177.
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