Article Data

  • Views 292
  • Dowloads 32

Original Research

Open Access

Validity of Signal Peptide-CUB-EGF Domain-containing Protein-1 (SCUBE-1) in the Diagnosis of Aortic Dissection

  • Adem Çakır1
  • Umut Payza2
  • Saliha Aksun3
  • Ahmet Kayalı2
  • Zeynep Karakaya2
  • Fatih Esad Topal2

1Department of Emergency Medicine, The Ministry of Health Basaksehir City Hospital, Istanbul, Turkey

2Department of Emergency Medicine, Izmir Katip Çelebi University Atatürk Training and Research Hospital, Izmir, Turkey

3Departmant of Biochemistry, Izmir Katip Celebi University Atatürk Traning and Researh Hospital, Izmir, Turkey

DOI: 10.22514/sv.2020.16.0043 Vol.17,Issue 1,January 2021 pp.112-116

Published: 08 January 2021

*Corresponding Author(s): Adem Çakır E-mail: dr.ademcakir@hotmail.com

Abstract

Introduction: Diagnosing aortic dissection (AD) in emergency services still represents a challenging issue as it may manifest not only well-known clinical findings such as sudden onset and severe chest pain but also atypical findings similar to ST elevation myocardial infarction or renal colic. Contrast-enhanced imaging investigations, which are expensive and risky due to possible complications, are necessary for diagnosis. Ultrasonography is not always reliable, which necessitates noninvasive diagnostic tests to support a clinical suspicion. Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor) domain-containing protein 1 (SCUBE-1) is a cell surface protein produced during embryogenesis. This study was conducted to compare the levels of this novel biomarker between patients with AD and healthy volunteers. Methods: This prospective study was conducted on 20 patients diagnosed with AD using contrast-enhanced thoracoabdominal computed tomography angiography. Average age-matched 20 healthy subjects as a control group were included as a reference for biochemical parameters. Results: The mean SCUBE-1 levels were significantly higher in patients with AD [24.51 ( ± 3.01) ng/dL] than in the control group [12.11 ( ± 5.31) ng/dL] (p < 0.001). Receiver-operating characteristic (ROC) curve was plotted to analyze the specificity and sensitivity of AD diagnosis (with 95% confidence intervals), which revealed 95% sensitivity and 76% specificity when the SCUBE-1 level was >19.75 ng/dL.A significant correlation was also observed between dissection types and mortality, as well as extravasation state. Conclusions: This preliminary study demonstrated that plasma SCUBE-1 level is a better and specific biomarker for AD and may be used for diagnosing AD in emergency services. Wider case series and further clinical studies are required to confirm these findings.

Keywords

SCUBE-1, Aortic dissection, Emergency service

Cite and Share

Adem Çakır,Umut Payza,Saliha Aksun,Ahmet Kayalı,Zeynep Karakaya,Fatih Esad Topal. Validity of Signal Peptide-CUB-EGF Domain-containing Protein-1 (SCUBE-1) in the Diagnosis of Aortic Dissection. Signa Vitae. 2021. 17(1);112-116.

References

[1] Johnson LouiseGA, Prince A. Aortic dissection and related aortic syndromes. In: Tintinalli JE, Stapczynski JS, Ma JO (editors). Tintinalli’s Emergency Medicine:a A Comprehensive Study Guide, 8th ed. New York, NY: McGraw-Hill Companies Inc. 2016:412-416.

[2] Kline JA. Thromboembolism. In: Tintinalli JE, Stapczynski JS, Ma JO (editors). Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8th ed. New York, NY: The McGraw-Hill Companies Inc. 2016:388-8.

[3] Nitta K, Imamura H, Kashima Y, et al. Impact of a negative D-dimer result on the initial assessment of acute aortic dissection. Int J Cardiol. 2018;258:232-236.

[4] Nitta K, Imamura H, Kashima Y, et al. Response to letter from Jiang: The diagnostic value of combined D-dimer with other indicators in suspected acute aortic dissection patients. Int J Cardiol. 2018;267:196.

[5] Tu CF, Su YH, Huang YN, et al. Localization and characterization of a novel secreted protein SCUBE1 in human platelets. Cardiovasc Res. 2006;71:486-495.

[6] Yang RB, Ng CKD, Wasserman SM, et al. Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. J Biol Chem. 2002;277:46364-46373.

[7] Acıpayam C, Tuncel DA, Güneş H, et al. Investigation Of Scube-1 Levels İn Pediatric Patients With Beta-Thalassemia. J Surg Med. 2019;3:825-828.

[8] Dai DF, Thajeb P, Tu C-F, et al. Plasma concentration of SCUBE1, a novel platelet protein, is elevated in patients with acute coronary syndrome and ischemic stroke. Am College Cardiol. 2008;51:2173-2180.

[9] Turkmen S, Mentese S, Mentese A, et al. The value of signal peptide-CUB-EGF domain-containing protein 1 and oxidative stress parameters in the diagnosis of acute mesenteric ischemia. Acad Emergency Med. 2013;20:257-264.

[10] Turkmen S, Sahin A, Gunaydin M , et al. The value of signal peptide-cub-egf domain-containing protein-1 (SCUBE1) in the diagnosis of pulmonary embolism: a preliminary study. Acad Emerg Med. 2015;22:922-926.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

IndexCopernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time

Conferences

    Top