Validity of Signal Peptide-CUB-EGF Domain-containing Protein-1 (SCUBE-1) in the Diagnosis of Aortic Dissection
1Department of Emergency Medicine, The Ministry of Health Basaksehir City Hospital, Istanbul, Turkey
2Department of Emergency Medicine, Izmir Katip Çelebi University Atatürk Training and Research Hospital, Izmir, Turkey
3Departmant of Biochemistry, Izmir Katip Celebi University Atatürk Traning and Researh Hospital, Izmir, Turkey
DOI: 10.22514/sv.2020.16.0043 Vol.17,Issue 1,January 2021 pp.112-116
Published: 08 January 2021
Introduction: Diagnosing aortic dissection (AD) in emergency services still represents a challenging issue as it may manifest not only well-known clinical findings such as sudden onset and severe chest pain but also atypical findings similar to ST elevation myocardial infarction or renal colic. Contrast-enhanced imaging investigations, which are expensive and risky due to possible complications, are necessary for diagnosis. Ultrasonography is not always reliable, which necessitates noninvasive diagnostic tests to support a clinical suspicion. Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor) domain-containing protein 1 (SCUBE-1) is a cell surface protein produced during embryogenesis. This study was conducted to compare the levels of this novel biomarker between patients with AD and healthy volunteers. Methods: This prospective study was conducted on 20 patients diagnosed with AD using contrast-enhanced thoracoabdominal computed tomography angiography. Average age-matched 20 healthy subjects as a control group were included as a reference for biochemical parameters. Results: The mean SCUBE-1 levels were significantly higher in patients with AD [24.51 ( ± 3.01) ng/dL] than in the control group [12.11 ( ± 5.31) ng/dL] (p < 0.001). Receiver-operating characteristic (ROC) curve was plotted to analyze the specificity and sensitivity of AD diagnosis (with 95% confidence intervals), which revealed 95% sensitivity and 76% specificity when the SCUBE-1 level was >19.75 ng/dL.A significant correlation was also observed between dissection types and mortality, as well as extravasation state. Conclusions: This preliminary study demonstrated that plasma SCUBE-1 level is a better and specific biomarker for AD and may be used for diagnosing AD in emergency services. Wider case series and further clinical studies are required to confirm these findings.
SCUBE-1, Aortic dissection, Emergency service
Adem Çakır,Umut Payza,Saliha Aksun,Ahmet Kayalı,Zeynep Karakaya,Fatih Esad Topal. Validity of Signal Peptide-CUB-EGF Domain-containing Protein-1 (SCUBE-1) in the Diagnosis of Aortic Dissection. Signa Vitae. 2021. 17(1);112-116.
 Johnson LouiseGA, Prince A. Aortic dissection and related aortic syndromes. In: Tintinalli JE, Stapczynski JS, Ma JO (editors). Tintinalli’s Emergency Medicine:a A Comprehensive Study Guide, 8th ed. New York, NY: McGraw-Hill Companies Inc. 2016:412-416.
 Kline JA. Thromboembolism. In: Tintinalli JE, Stapczynski JS, Ma JO (editors). Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8th ed. New York, NY: The McGraw-Hill Companies Inc. 2016:388-8.
 Nitta K, Imamura H, Kashima Y, et al. Impact of a negative D-dimer result on the initial assessment of acute aortic dissection. Int J Cardiol. 2018;258:232-236.
 Nitta K, Imamura H, Kashima Y, et al. Response to letter from Jiang: The diagnostic value of combined D-dimer with other indicators in suspected acute aortic dissection patients. Int J Cardiol. 2018;267:196.
 Tu CF, Su YH, Huang YN, et al. Localization and characterization of a novel secreted protein SCUBE1 in human platelets. Cardiovasc Res. 2006;71:486-495.
 Yang RB, Ng CKD, Wasserman SM, et al. Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. J Biol Chem. 2002;277:46364-46373.
 Acıpayam C, Tuncel DA, Güneş H, et al. Investigation Of Scube-1 Levels İn Pediatric Patients With Beta-Thalassemia. J Surg Med. 2019;3:825-828.
 Dai DF, Thajeb P, Tu C-F, et al. Plasma concentration of SCUBE1, a novel platelet protein, is elevated in patients with acute coronary syndrome and ischemic stroke. Am College Cardiol. 2008;51:2173-2180.
 Turkmen S, Mentese S, Mentese A, et al. The value of signal peptide-CUB-EGF domain-containing protein 1 and oxidative stress parameters in the diagnosis of acute mesenteric ischemia. Acad Emergency Med. 2013;20:257-264.
 Turkmen S, Sahin A, Gunaydin M , et al. The value of signal peptide-cub-egf domain-containing protein-1 (SCUBE1) in the diagnosis of pulmonary embolism: a preliminary study. Acad Emerg Med. 2015;22:922-926.
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