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Neuron-specific Enolase Level after the Onset of Delayed Neurological Sequelae with Acute Carbon Monoxide Intoxication

  • Sangsoo Han1
  • Sangun Nah1
  • Sungwoo Choi1
  • Young Hwan Lee1

1Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea

DOI: 10.22514/sv.2020.16.0042 Vol.17,Issue 1,January 2021 pp.200-204

Published: 08 January 2021

*Corresponding Author(s): Young Hwan Lee E-mail:


Background: Delayed neurological sequelae (DNS) is a major problem in carbon monoxide (CO) intoxication. Many other studies have showed whether serum NSE of acute phase can predict DNS in CO poisoning. However, no study has examined NSE levels after development of DNS. Therefore, we report serum NSE levels after the onset of DNS. Case presentation: We described the NSE levels in two cases of DNS. The first was a 33-year-old woman who presented with concentration problems 39 days after CO exposure. The second was a 51-year-old woman who presented with gait disturbance and urinary incontinence 23 days after CO exposure. Brain magnetic resonance imaging (MRI) and NSE levels were obtained in both patients. Brain MRI confirmed brain injury and the diagnosis of DNS was made. The NSE levels of the two patients were 12.51 and 16.18 ng/mL, respectively. Conclusion: Although the initial NSE elevated level may be useful in the prediction of carbon monoxide induced DNS, it may be decreased to normal reference range after the onset of DNS.


Brain injury, Carbon monoxide, Complications, Poisoning, Neuron specific enolase

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Sangsoo Han,Sangun Nah,Sungwoo Choi,Young Hwan Lee. Neuron-specific Enolase Level after the Onset of Delayed Neurological Sequelae with Acute Carbon Monoxide Intoxication. Signa Vitae. 2021. 17(1);200-204.


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