Article Data

  • Views 86
  • Dowloads 5

Original Research

Open Access

Dexmedetomidine on Continuous Infraclavicular Block after Elbow Arthrolysis

  • Shuishui Wu1
  • Zongjian Sun1
  • Ronghua Li1
  • Ling Li1

1Department of Anesthesiology, Cangzhou Central Hospital, Cangzhou, P. R. China

DOI: 10.22514/sv.2020.16.0017 Vol.16,Issue 1,June 2020 pp.131-135

Published: 30 June 2020

*Corresponding Author(s): Zongjian Sun E-mail:

PDF (207.64 kB)


Aim: To evaluate the efficacy of dexmedetomidine in the analgesia of contin-uous infraclavicular brachial plexus block after elbow arthrolysis. Methods: Sixty patients who received unilateral elbow arthrolysis and met inclusion criteria were randomly divided into 2 groups (n = 30): dexmedetomidine + ropivacaine group (group D) and ropivacaine group (group R). The formulation of analgesic pump was 0.2% ropivacaine 240 mL + 2 ug/kg dexmedetomidine in D group and 0.2% ropivacaine 240 mL in R group. The VAS scores at rest, 4 h (T1), 8 h (T2), 12 h (T3), 24 h (T4), 36 h (T5) and 48 h (T6) after operation were recorded, and NRS scores during functional exercise at 24 h (T4), 36 h (T5) and 48 h (T6) after operation were recorded. The incidence of adverse reactions and satisfactory degree of analgesia in two groups were recorded. Results: The success rate of block during catheterization was 100% in both groups. Compared with group R, VAS score of group D at each time point after operation decreased (p < 0.05); NRS score during functional exercise at each time point after operation decreased (p < 0.05); the additional pressing times of analgesic pump within 48 h decreased (p < 0.05); the incidence of dizziness, nausea and vomiting after operation decreased (p < 0.05); and satisfaction degree of analgesia 48 h after operation was higher in group D (p < 0.05). Conclusion: Dexmedetomidine combined with ropivacaine can produce effective analgesic and sedative effects, and reduce the incidence of complications in the analgesia of continuous infraclavicular brachial plexus block after elbow arthrolysis.

Key words

Dexmedetomidine, Brachial plexus block, Elbow joint, Analgesia, Pain

Cite And Share

Shuishui Wu,Zongjian Sun,Ronghua Li,Ling Li. Dexmedetomidine on Continuous Infraclavicular Block after Elbow Arthrolysis. Signa Vitae. 2020. 16(1);131-135.


[1] Sun Z, Cui H, Liang J, et al. Determining the effective timing of an open arthrolysis for post-traumatic elbow stiffness: a retrospective cohort study. BMC Musculoskelet Disord. 2019;20:122.

[2] McGrath B, Elgendy H, Chung F, et al. Thirty percent of patients have moderate to severe pain 24 hr after ambulatory surgery: a survey of 5,703 patients. Can J Anaesth. 2004;51:886–891.

[3] Dhir S, Brown B, Mack P, et al. Infraclavicular and supraclavicular approaches to brachial plexus for ambulatory elbow surgery: A randomized controlled observer-blinded trial. J Clin Anesth. 2018;48:67–72.

[4] Yeo J, Park S. Effect of dexmedetomidine on the development of mechanical allodynia and central sensitization in chronic post-ischemia pain rats. J Pain Res. 2018;11:3025–3030.

[5] Chen Q, Liu X, Zhong X, et al. Addition of dexmedetomidine or fentanyl to ropivacaine for transversus abdominis plane block: evaluation of effect on postoperative pain and quality of recovery in gynecological surgery. J Pain Res. 2018;11:2897–2903.

[6] Sun Z, Wang B, Niu Z, et al. Dexmedetomidine improves continuous interscalene brachial plexus block in patients after arthroscopic rotator cuff repair. Int J Clin Exp Med. 2018;11:4168–4172.

[7] Czarnik T, Gawda R, Nowotarski J. Real-time ultrasound-guided infraclavicular axillary vein cannulation: A prospective study in me-chanically ventilated critically ill patients. J Crit Care. 2016;33:32–37.

[8] Harrison TK, Kim TE, Howard SK, et al. Comparative effective-ness of infraclavicular and supraclavicular perineural catheters for ultrasound-guided through-the-catheter bolus anesthesia. J Ultra-sound Med. 2015;34:333–340.

[9] Lv M, Zhang P, Wang Z. ED50 of intrathecal ropivacaine for cesarean delivery with and without epidural volume extension with normal saline: a randomized controlled study. J Pain Res. 2018;11:2791–2796.

[10] Singh AP, Kohli V, Bajwa SJ. Intravenous analgesia with opioids versus femoral nerve block with 0.2% ropivacaine as preemptive analgesic for fracture femur: A randomized comparative study. Anesth Essays Res. 2016;10:338–342.

[11] Marhofer D, Kettner SC, Marhofer P, et al. Dexmedetomidine as an adjuvant to ropivacaine prolongs peripheral nerve block: a volunteer study. Br J Anaesth. 2013;110:438–442.

[12] Fritsch G, Danninger T, Allerberger K, et al. Dexmedetomidine added to ropivacaine extends the duration of interscalene brachial plexus blocks for elective shoulder surgery when compared with ropiva-caine alone: a single-center, prospective, triple-blind, randomized controlled trial. Reg Anesth Pain Med. 2014;39:37–47.

[13] Ouchi K, Sugiyama K. Dexmedetomidine Dose Dependently En-hances the Local Anesthetic Action of Lidocaine in Inferior Alveolar Nerve Block: A Randomized Double-Blind Study. Reg Anesth Pain Med. 2016;41:348-55.

[14] Brummett CM, Norat MA, Palmisano JM, et al. Perineural ad-ministration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat. Anesthesiology. 2008;109:502–511.

[15] Gaumann DM, Brunet PC, Jirounek P. Clonidine enhances the effects of lidocaine on C-fiber action potential. Anesth Analg. 1992;74:719–725.

[16] Uslusoy, F, Naziroglu M. An extract of Hypericum perforatum induces wound healing through inhibitions of Ca2+ mobilizations, mitochondrial oxidative stress and cell death in epithelial cells: Involvement of TRPM2 channels. Biocell. 2019;43:271–283.

[17] Dai S, Qi Y, Fu J, et al. Dexmedetomidine attenuates persistent postsurgical pain by upregulating K+-Cl- cotransporter-2 in the spinal dorsal horn in rats. J Pain Res. 2018;11:993–1004.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) The Science Citation Index (SCI) is a citation index originally produced by the Institute for Scientific Information (ISI) and created by Eugene Garfield. It (Science Citation Index Expanded) covers more than 8,500 notable and significant journals, across 150 disciplines in science and technology, from 1900 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

IndexCopernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time

Editorial review: 1 - 2 days

Peer review: 1 - 2 months

Ahead of Print: within 2 months after being accepted

Notes: Your information is kept confide-ntial throughout the review process.