Protecting mitochondrial bioenergetic function
1Resuscitation Institute a Rosalind Franklin University Section of Critical Care Medicine Medical Service at the James A. Lovell Federal Health Care Center
DOI: 10.22514/SV51.092010.7 Vol.5,Issue S1,September 2010 pp.32-35
Published: 07 September 2010
Reversal of cardiac arrest requires reestablishment of aerobic metabolism by reperfusion with oxygenated blood of tissues that have been ischemic for variables periods of time. However, reperfusion concomitantly activates a myriad of pathogenic mechanisms causing what is known as “reperfusion injury.” At the center of reperfusion injury are mitochondria, playing a critical role as effectors and targets of injury. Mitochondrial injury compromises oxidative phosphorylation and the ability to regenerate Adenosine-5'-triphosphate (ATP); i.e., bioenergetic function. Thus targeting mitochondria to protect bioenergetic function may represent a novel concept in resuscitation with the potential for altering clinical practice. We have identified sodium-hydrogen exchanger isoform-1 (NHE)-1 inhibition and erythropoietin as attractive candidate drugs for this purpose and demonstrated corresponding functional and clinical benefits. Further work on the subject may pave the way for further scientific discover focused on greater understating of underlying cell mechanisms, identification of additional and perhaps more potent strategies, and develop means for effective drug delivery.
cardiac arrest, reper-fusion injury, mitochondria, bioen-ergetic function, left ventricular myo-cardial distensibility, sodium-hydro-gen exchanger isoform-1 (NHE-1) inhibitors, erythropoietin
RAÚL J. GAZMURI ,IYAD M. AYOUB,JEEJABAI RADHAKRISHNAN. Protecting mitochondrial bioenergetic function. Signa Vitae. 2010. 5(S1);32-35.
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