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Original Research

Open Access

Early instrumental predictors of long term neurodevelopmental impairment in newborns with perinatal asphyxia treated with therapeutic hypothermia


1Division of Pediatrics, Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy

2 Division of Neonatal Intensive Care Unit, Azienda Ospedaliero-Universitaria “Maggiore della Carità”, Novara, Italy

3 Division of Child Neurology and Psychiatry, Azienda Ospedaliero-Universitaria “Maggiore della Carità”, Novara, Italy

DOI: 10.22514/SV141.042018.14 Vol.14,Issue 1,March 2018 pp.81-85

Published: 27 March 2018

*Corresponding Author(s): ALICE MONZANI E-mail:


Background. Hypoxic-ischemic encepha-lopathy (HIE) is a leading cause of dis-ability in full-term newborns. Long-term consequences of HIE, even when treated by hypothermia, are not easily predictable. Aims. To assess the potential role of elec-troencephalography and neuroimaging parameters as early predictors of neurode-velopmental outcome in HIE newborns treated with hypothermia.

Methods. We retrospectively evaluated 13 HIE patients treated with hypothermia in January 2012-September 2014. We re-viewed their amplitude-integrated electro-encephalography (a-EEG) at 6, 12 and 24 hours (h), cranial ultrasonography (US) at 12, 72 h and >7 days of life (DOL) and brain magnetic resonance (MRI) performed at 7-28 DOL, according to validated scores. aEEG, US and MRI patterns were correlat-ed to neurodevelopmental outcome at 18-24 months, considered as negative if one of the following was present: Mental Devel-opment Index (MDI)<85, motor, visual or hearing impairment.

Results. The severity of a-EEG, US and MRI alterations at each time point was not different according to the outcome. MDI was negatively correlated with aEEG score at 12h (R= -0.571, p=0.04) and with US score at 72h (R= -0.630, p=0.02). A positive correlation was found between aEEG score at 6h and US score at >7DOL(R=0.690, p=0.013). US alterations of the cortical matter at 72h were directly corre-lated with a-EEG score at 12h (R = 0.606, p=0.028) and 24h (R=0.605, p=0.029). Conclusions. Early instrumental evalua-tions, in particular aEEG and US, seem to predict neurodevelopmental outcome at 18-24 months in HIE newborns treated with hypothermia. 


asphyxia, hypoxic-ischemic en-cephalopathy, hypothermia, newborn

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ALICE MONZANI,GIANLUCA COSI,GIULIA GENONI,MARIA LAVRANO,CINZIA PERUZZI,ROBERTA POMELLA,FEDERICA FERRERO. Early instrumental predictors of long term neurodevelopmental impairment in newborns with perinatal asphyxia treated with therapeutic hypothermia. Signa Vitae. 2018. 14(1);81-85.


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