Article Data

  • Views 1982
  • Dowloads 159

Original Research

Open Access

Impact of prehospital rapid sequence intubation and mechanical ventilation on prehospital vital signs and outcome in trauma patients

  • TINE PELCL1
  • VESNA BOROVNIK LESJAK1
  • VITKA VUJANOVIĆ1
  • MATEJ STRNAD2

1Center for Emergency Medicine Maribor, Maribor, Slovenia

2Medical Faculty, University of Maribor, Maribor, Slovenia

DOI: 10.22514/SV131.042017.23 Vol.13,Issue 1,March 2017 pp.51-55

Published: 20 March 2017

*Corresponding Author(s): TINE PELCL E-mail: tpelcl1@gmail.com

Abstract

Introduction. Medications during rapid se-quence intubation (RSI) have known detri-mental side effects. Prehospital mechanical ventilation after successful endotracheal intubation also increases mortality due to hyperventilation and positive pressure ventilation. The aim of this retrospective analysis was to determine the impact of RSI on prehospital hemodynamic param-eters and prehospital ventilation status on mortality rate and functional outcome in trauma patients.

Methods. Charts of 73 trauma patients, who underwent prehospital RSI over a 12-year period, were retrospectively reviewed. Prehospital vital signs, before and after RSI, were compared. Patients were divided, according to ventilation status, into three groups based on initial PaCO2: hypocar-bic/hyperventilated (PaCO2<35mmHg), normocarbic/normoventilated (PaCO2 35-45 mmHg) and hypercarbic/hypoven-tilated (PaCO2>45mmHg).

Results. Seventy-three patients were en-rolled in the retrospective analysis. There was a significant difference in respira-tory rate (p=0.046), arterial oxygen satu-ration (p<0.001), mean arterial pressure (p<0.001) and Glasgow Coma Scale (GCS)(p<0.001) before and after RSI. GCS at dis-charge (p=0.003) and arterial oxygen satu-ration (p=0.05) were significantly higher in the normoventilated group. There was no significant difference in survival to hospi-tal discharge among compared groups. Conclusion. Our retrospective analysis suggests that prehospital RSI has no detri-mental hemodynamic side effects and that normoventilation leads to a favorable neu-rological outcome.

Keywords

intubation, prehospital, me-chanical ventilation, trauma, hemodynam-ics

Cite and Share

TINE PELCL,VESNA BOROVNIK LESJAK,VITKA VUJANOVIĆ,MATEJ STRNAD. Impact of prehospital rapid sequence intubation and mechanical ventilation on prehospital vital signs and outcome in trauma patients. Signa Vitae. 2017. 13(1);51-55.

References

1. Mace SE. Challenges and advances in intubation: rapid sequence intubation. Emerg Med Clin North Am 2008;26:1043-68.

2. Ballow SL, Kaups KL, Anderson S, Chang M. A standardized rapid sequence intubation protocol facilitates airway management in critically injured patients. J Trauma Acute Care Surg 2012;73:1401-5.

3. Lin CC, Chen KF, Shih CP, Seak CJ, Hsu KH. The prognostic factors of hypotension after rapid sequence intubation. Am J Emerg Med 2008;26:845-51.

4. Shapiro NI, Kociszewski C, Harrrison T, Chang Y, Wedel SK, Thomas SH. Isolated prehospital hypotension after traumatic injury: a predictor of mortality? J Emerg Med 2003;25:175-9.

5. Sivilotti MLA, Ducharme J. Randomized, double-blind study on sedatives and hemodynamics during rapid-sequence intubation in the emergency department: The SHRED Study. Ann Emerg Med 1998:313-24.

6. Murray JA, Demetriades D, Berne TV, Stratton SJ, Cryer HG, Bongard F, et al. Prehospital intubation in patients with severe head injury. J Trauma 2000; 49:1065-70.

7. Davis DP, Peay J, Sise MJ, Vilke GM, Kennedy F, Eastman AB, et al. The impact of prehospital intubation on outcome in moderate to severe traumatic brain injury. J Trauma 2005; 58:933-9.

8. Muizelaar JP, Marmarou A, Ward JD, Kontos HA, Choi SC, Becker DP, et al. Adverse effects of prolonged hyperventilation in patients with severe head injury: a randomized clinical trial. J Neurosurg 1991; 75:731-9.

9. Pepe PE, Raedler C, Lurie KG, Wiggintoon JG. Emergency ventilator management in severe hemorrhagic states: elemental or detri-mental? J Trauma 2003; 54:1048-55.

10. Chesnut RM, Marshall LF, Klauber MR, Blunt BA, Baldwin N, Eisenberg HM, et al. The role of secondary brain injury in determining outcome from severe head injury. J Trauma 1993; 34:216-22.

11. The Brain Trauma Foundation, American Association of Neurological Surgeons, Congress of Neurological Surgeons. 2007; Joint Section on Neurotrauma and Critical Care; AANS/CNS. Guidelines for the management of severe traumatic brain injury. VI. Indica-tions for intracranial pressure monitoring. J Neurotrauma 2007;24:S37-S44.

12. Chi JH, Knudson MM, Vassar MJ, McCarthy MC, Shapiro MB, Mallet S, et al. Prehospital hypoxia affects outcome in patients with traumatic brain injury: A prospective multicenter study. J Trauma 2006; 61:1134-41.

13. Chang JJ, Youn TS, Benson D, Mattick H, Andrade N, Harper CR, et al. Physiologic and functional outcome correlates of brain tissue hypoxia in traumatic brain injury. Crit Care Med 2009;37:283-90.

14. Valadka AB, Gopinath SP, Contant CF, Uzura M, Robertson CS. Relationship of brain tissue PO2 to outcome after severe head injury. Crit Care Med 1998; 26:1576-81.

15. Heffner AC, Swords DS, Nussbaum ML, Kline JA, Jones AE. Predictors of the complication of postintubation hypotension during emergency airway management. J Crit Care 2012;27:587-93.

16. Jeanne M, Logier R, De Jonckheere J, Tavernier B. Validation of a graphic measurement of heart rate variability to asses analgesia/nociception balance during general anesthesia. Conf Proc IEEE Eng Med Biol Soc 2009;2009:1840-3.

17. Logier R, Jeanne M, Tavernier B, De Jonckheere J. Pain/analgesia evaluation using heart rate variability analysis. Conf Proc IEEE Eng Med Biol Soc 2006;1:4303-6.

18. Kogler VM, Deutsch J, Sakan S. Analgesia and sedation in hemodynamic unstable patient. Signa Vitae 2008;3:S10-S12.

19. Choi YF, Wong TW, Lau CC. Midazolam is more likely to cause hypotension then etomidate in emergency department rapid se-quence intubation. Emerg Med J 2004 21:700-2.

20. Wang HE, Peitzman AB, Cassidy LD, Adelson PA, Yealy DM. Out-of-hospital endotracheal intubation and outcome after traumatic brain injury. Ann Emerg Med 2004;44:439-50.

21. Eckstein M, Chan L, Schneir A, Palmer R. Effect of prehospital advanced life support on outcomes of major trauma patients. J Trauma 2000;48:643-8.

22. Davis DP, Dunford JV, Poste JC, Ochs M, Holbrook T, Fortlage D, et al. The impact of hypoxia and hyperventilation on outcome after paramedic rapid sequence intubation of severely head-injured patients. J Trauma 2004;57:1-8.

23. Wang HE, Balasubramani GK, Cook LJ, Lave JR, Yealy DM. Out-of-hospital endotracheal intubation experience and patients out-comes. Ann Emerg Med 2010; 55:527-37.

24. Davis DP, Peay J, Sise MJ, Kennedy F, Simon F, Tominaga G, et al. Prehospital airway and ventilation management: A trauma score and injury severity score-based analysis. J Trauma 2010;69:294-301.

25. Sloane C, Vilke GM, Chan TC, Hayden SR, Hoyt DB, Rosen P. Rapid sequence intubation in the field versus hospital in trauma pa-tients. J Emerg Med 2000;19:259-64.

26. Katz SH, Falk JL. Misplaced endotracheal tubes by paramedics in an urban emergency medical services system. Ann Emerg Med 2001;37:32-7.

27. Dunford JV, Davis DP, Ochs M, Doney M, Hoyt DB. Incidence of transient hypoxia and pulse rate reactivity during paramedic rapid sequence intubation. Ann Emerg Med 2003;42:721-8.

28. Davis DA, Idris AH, Sise MJ, Kennedy F, Eastman AB, Velky T, et al. Early ventilation and outcome in patients with moderate to severe traumatic brain injury. Crit Care Med 2006;34:1202-8.

29. Rangel-Castilla L, Rivera Lara L, Gopinath S, Swank PR, Valadka A, Robertson C. Cerebral hemodynamic effects of acute hyperoxia and hyperventilation after severe traumatic brain injury. J Neurotrauma 2010;27:1853-63.

30. The Brain Trauma Foundation, American Association of Neurological Surgeons, Congress of Neurological Surgeons. 2007; Joint Section on Neurotrauma and Critical Care; AANS/CNS. Guidelines for the management of severe traumatic brain injury. XIV. Hy-perventilation. J Neurotrauma 2007;24:S87-S90.

31. Dumont TM, Visioni AJ, Rughani AI, Tranmer BI, Crookes B. Inappropriate prehospital ventilation in severe traumatic brain injury increases in hospital mortality. J Neurotrauma 2010;27:1233-41.

32. Thomas FO, Hoffman TL, Handrahan DL, Crapo RO, Snow G. The measure of treatment agreement between portable and laboratory blood gas measurements in guiding protocol-driven ventilator management. J Trauma 2009;67:303-13.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 1.0 (2022) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time

Conferences

Top