Clonidine for neonatal abstinence syndrome: a single neonatology department’s experience
1Division of Paediatrics, Department of Neonatology, University Medical Centre of Ljubljana, Ljubljana, Slovenia
2Institute of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
DOI: 10.22514/SV121.102016.20 Vol.12,Issue S1,October 2016 pp.116-118
Published: 10 October 2016
Clonidine has been shown effective in reducing sympathetic hyperactivity in neonatal abstinence syndrome (NAS). The aim of this study was to analyze clinical and laboratory characteristics of a group of newborns treated with clonidine for NAS due to maternal drug addiction and due to withdrawal from opioid analgesic therapy. Only one full–term newborn presented with metabolic acidosis and hyperkalemia; in others no clinical or laboratory adverse effects were detected. This report empha-sizes the importance of alertness to poten-tial adverse effects of clonidine therapy, and discusses possible pathophysiological aspects of hyperkalemia and metabolic aci-dosis during treatment for NAS.
newborn, sympathetic hyperac-tivity, metabolic acidosis, hyperkalemia
PETJA FISTER,MOJCA KRZAN,DARJA PARO-PANJAN. Clonidine for neonatal abstinence syndrome: a single neonatology department’s experience. Signa Vitae. 2016. 12(S1);116-118.
1. Bada HS, Sithisarn T, Gibson J, Garlitz K, Caldwell R, Capilouto G, et al. Morphine versus clonidine for neonatal abstinence syn-drome. Pediatrics 2015;135:e383–91.
2. Bio LL, Siu A, Poon CY. Update on the pharmacologic management of neonatal abstinence syndrome. J Perinatol 2011;31:692–701.
3. Finnegan LP, Connaughton JFR, Kron RE, Emich JP. Neonatal abstinence syndrome: assessment and management. Addict Dis 1975;2:141–58.
4. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reac-tions. Clin Pharmacol Ther 1981;30:239–45.
5. Agthe AG, Kim GR, Mathias KB, Hendrix CW, Chavez-Valdez R, et al. Clonidine as an adjunct therapy to opioids for neonatal absti-nence syndrome: a randomized, controlled trial. Pediatrics 2009;123:e849–56.
6. Martinerie L, Pussard E, Foix-L’Helias L, Petit F, Cosson C, Boileau P, Lombes M. Physiological partial aldosterone resistance in hu-man newborns. Pediatr Res 2009;66:323–8.
7. Karet FE. Mechanisms in hyperkalemic renal tubular acidosis. J Am Soc Nephrol 2009;20: 251–4.
8. Hoder EL, Leckman JF, Poulsen J, Caruso KA, Ehrenkranz RA, Kleber HD, Cohen DJ. Clonidine treatment of neonatal narcotic abstinence syndrome. Psychiatry Res 1984;13:243–51.
Science Citation Index Expanded (SciSearch) The Science Citation Index (SCI) is a citation index originally produced by the Institute for Scientific Information (ISI) and created by Eugene Garfield. It (Science Citation Index Expanded) covers more than 8,500 notable and significant journals, across 150 disciplines in science and technology, from 1900 to the present.
Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.
Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.
IndexCopernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.
Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.
Scopus Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.
Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.