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Original Research

Open Access

What affects the outcome of severe preeclampsia?


1Department of OB/GYN, School of Medicine, University of Zagreb, Zagreb, Croatia

2University of Applied Health Sciences, Zagreb, Croatia

DOI: 10.22514/SV101.062015.1 Vol.10,Issue S1,June 2015 pp.6-12

Published: 22 June 2015

*Corresponding Author(s): PETRANA BELJAN E-mail:

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Preeclampsia is a severe multi-system pregnancy related disorder associated with multiple maternal and fetal adverse out-comes, including fetal and maternal mor-tality. The aim of this study is to investigate the clinical difference between early- and late-onset preeclampsia and their impact to perinatal outcome, and to detect pos-sible antenatal parameters that can predict adverse fetal and maternal outcomes. The research team conducted a retrospective cohort study of 308 singleton pregnan-cies complicated with severe preeclamp-sia over an 8-year period in our tertiary level centre. Clinical differences and perinatal outcomes between early- (<34 weeks, n=147) and late-onset (≥34 weeks, n=161) preeclampsia were analyzed. Pos-sible antenatal risk factors that can influ-ence adverse perinatal outcomes in severe preeclampsia were also evaluated. Clinical symptoms and perinatal outcomes were significantly unfavourable in early-onset preeclampsia. Adverse perinatal outcomes in the early-onset group were complicated with 10 (6.08%) intrauterine fetal deaths and 4 (2.37%) neonatal deaths. Primipa-rity seems to be the significant antenatal risk factor for appearance of early-onset of the disease (p<0.001, OR 2.39, 95% CI 1.48-3.86) and for the first minute Apgar score <7 (p=0.036, OR 1.68, 95% CI 1.04-2.74). Patients with severe preeclampsia are high- risk obstetric patients because of the unpredictability, varying clinical pres-entation and potential adverse outcomes of the disease. Pregnant women with an early appearance of the disease had severe clinical presentation and more often an unfavourable perinatal outcome.

Key words

early-onset preeclampsia, peri-natal outcome, HELLP

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