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Case Report

Open Access

Gestational trophoblastic disease with multisistemic complications

  • DEJAN PEJIĆ1
  • SAŠA SAVIĆ2
  • MIROSLAV POPOVIĆ2
  • ARNELA CERIĆ BANIČEVIĆ2
  • BARBARA STANIMIROVIĆ3
  • JELENA MRĐA4

1General Hospital Gradiška, Gradiška

2Clinic of Obstetrics and Gynecology, University Hospital, Clinical Centre, Banjaluka

3Clinic of Paediatrics, University Hospital, Clinical Center, Banjaluka

4Clinic of Internal medicine, University Hospital, Clinical Centre, Banjaluka, Bosnia and Herzegovina

DOI: 10.22514/SV101.062015.24 Vol.10,Issue S1,June 2015 pp.79-80

Published: 22 June 2015

*Corresponding Author(s): DEJAN PEJIĆ E-mail: dejanpejic80@hotmail.com

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Abstract

Gestational trophoblastic disease (GTD) is a condition of uncertain etiology, com-prised of a hydatidiform mole (complete and partial), invasive mole, choriocarcino-ma, epithelioid trophoblastic tumour and placental site trophoblastic tumour.

A partial hydatidiform mole develops when dispermy occurs, and the resulting conceptus is triploidy. 

A 26-year-old woman (Gravida 2, Para 1, with one previous vaginal delivery of a normal female infant) was 16 weeks preg-nant and was scheduled for emergency surgical treatment. She was diagnosed with a hydatidiform mole and eclampsia in our hospital for further treatment.

Her pre-treatment beta human chorionic gonadotropin (β-HCG) level was extreme-ly high at 1,082,900 mIU/ml. The obste-tricians considered septic complications from the hydatidiform mole and we decid-ed to perform an emergency Sectio parva. Two weeks after delivery, the serum β-hCG level was 16,341 mlU/mL and normalized gradually within two months without any cytotoxic therapy.

Partial mole hydatidosa (PMH), as a milder form of GTD, can go along with malignant complications with fatal consequences.

Key words

gestational trophoblastic disease, eclampsia, chorionic gonadotropin beta sub-unit

Cite And Share

DEJAN PEJIĆ,SAŠA SAVIĆ,MIROSLAV POPOVIĆ,ARNELA CERIĆ BANIČEVIĆ,BARBARA STANIMIROVIĆ,JELENA MRĐA. Gestational trophoblastic disease with multisistemic complications. Signa Vitae. 2015. 10(S1);79-80.

References

1. Abeloff M, Armitage J, Niederhuber J. Abeloff`s clinical oncology. Philadelphia . Churchill Livingstone Elsevier. 2008

2. Allen SD, Lim AK, Seckl MJ, Blunt DM, Mitchell AW. Radiology of gestational trophoblastic neoplasia. Clinical Radiology. 2006;61(4):301–313. [PubMed]

3. Montes-de-Oca-Valero F, Macara L, Shaker A. Twin pregnancy with a complete mole and co-existing fetus following in vitro ferti-lization. Hum Reprod. 1999;14:2905–2907. [PubMed]/

4. Vaisbuch E, Ben-Arie A, Dgani R, Perlman S, Sokolovsky N, Hagay Z. Twin pregnancy consisting of a complete hydatidiform mole and co-existent fetus: report of two cases and review of literature. Gynecol Oncol. 2005;98:19–23. [PubMed]

5. Cunningham G, Leveno C, Bloom S, Hauth J et al. Williams Obstetrics. Parkland. McGraw – Hill Professional Publishing. 2010.

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